Neoscept 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, morning administration of this drug may be considered. Since donepezil concentrations reach steady state 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose escalation, the 5 mg dose should be administered for 4~6 weeks. After assessing the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. When this drug is discontinued, its effects gradually diminish, and no rebound effect occurs with abrupt discontinuation. Women aged 85 years or older with low body weight: Adverse reactions occur frequently, so careful monitoring is required. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

Pediatric patients: There is no experience with use in pediatric patients.

This medication contains the ingredient Donepezil Hydrochloride, primarily used for the treatment of symptoms of Alzheimer's type dementia. Firstly, this medication should not be administered to certain patients. For example, individuals allergic to this medication or its components, women who are pregnant or might become pregnant, and patients with genetic issues such as lactose intolerance should not use this medication. Moreover, patients with heart disease or conduction disorders, those with a history of peptic ulcers or currently taking nonsteroidal anti-inflammatory drugs, individuals with a history of asthma or obstructive pulmonary disease, patients with extrapyramidal disorders such as Parkinson's disease, and those allergic to the colorants included in this medication should use it with caution. While taking this medication, various adverse reactions may occur. Severe issues may arise that affect heart function, such as fainting, bradycardia, and heart block. Gastrointestinal issues such as peptic ulcers or gastric bleeding may also occur. Liver dysfunction, cerebrovascular problems, and muscle-related abnormal symptoms have been reported as well. Psychological changes may include hallucinations, anxiety, insomnia, and confusion; if these symptoms occur, consult a doctor immediately. This medication requires particular caution in patients with cardiovascular diseases, as it can affect heart rhythms and electrical signals, necessitating electrocardiogram tests. Additionally, this medication may impact driving or machinery operation abilities, so caution is needed at the early stages of use. Women who are pregnant or breastfeeding should ideally not use this medication; if absolutely necessary, they should consult a professional. Safety for children has not yet been established, and therefore it is not used in pediatric patients. This medication can interact with other drugs; thus, it is crucial to inform a doctor or pharmacist, especially when taking heart medications, antidepressants, antibiotics, or anti-inflammatory drugs. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate emergency treatment, and atropine can be used as an antidote. This medication must be kept out of reach of children, and transferring it to other containers is discouraged as it may affect quality.

• Syncope
• bradycardia
• heart block
• prolongation of QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforation of the duodenum
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a sealed container to prevent air or moisture ingress. It is also advisable to keep it at a temperature between 1 and 30 degrees Celsius (room temperature). Storing it this way helps maintain the medication's efficacy.

Appearance

White round film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 100 tablets/bottle