Hyunephecil Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, it is administered once a day at 5 mg before bedtime. If unusual dreams, nightmares, or insomnia occur, morning dosing may be considered. Donepezil reaches a steady state concentration 15 days after administration, so a dose of 5 mg should be administered for 4-6 weeks. After evaluating the clinical response, the dosage may be increased up to 10 mg, and if increased to 10 mg daily, caution needs to be taken regarding gastrointestinal adverse reactions.

Child dose

There is no experience of use in children.

This medication contains donepezil hydrochloride as its active ingredient and is used for the treatment of Alzheimer's type dementia symptoms. This medication should not be administered to certain patients. For example, those with allergies to this medication or its components, pregnant women or those who may become pregnant, breastfeeding women, and patients with genetic lactose intolerance should not use this medication. In patients with heart disease or a history of peptic ulcers, asthma or obstructive pulmonary disease, and patients with extrapyramidal disorders such as Parkinson's disease, this medication should be used with caution, as it may affect heart rate or exacerbate gastrointestinal symptoms. During treatment with this medication, various adverse reactions may occur. Reports have indicated issues such as heart problems, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, motor dysfunction, severe muscle problems, difficulty breathing, acute pancreatitis, acute kidney failure, and sudden death, among others. Common side effects may include nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, anxiety, headaches, and fatigue. This medication is approved only for patients with Alzheimer's type dementia and should not be used for other types of dementia or memory decline. Treatment should be carried out under the supervision of an experienced physician, and discontinuation should be considered if there is no therapeutic effect. Due to the risk of increasing heart arrhythmias, patients with heart disease or a history of QT interval prolongation may require regular electrocardiograms. Additionally, caution should be exercised with patients taking anti-inflammatory pain relievers to reduce the risk of gastrointestinal bleeding. This medication may affect driving or machinery operation, so caution is necessary during initial doses or dose changes. This medication may interact with other drugs; special caution is warranted when used with drugs that affect the CYP3A4 and CYP2D6 enzymes. Some muscle relaxants or anticholinergic medications may also interact with this medication. Women who are pregnant or breastfeeding should not use this medication, and if necessary, they should consult a specialist. Safety in pediatrics has not been established, so it should not be used in children. In cases of overdose, serious symptoms such as vomiting, bradycardia, seizures, and respiratory suppression may occur, and immediate medical attention is necessary. Atropine may be used as an antidote. This medication should be kept out of the reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, lightning headache, seizures, altered consciousness, vision changes, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• hallucinations
• excitement

This medication should be stored in a sealed container to prevent air or moisture access. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

Yellow spherical film-coated tablet

Package unit

30 tablets/bottle