Myungmoon Amoclan Tablet 625 Milligrams (Amoxicillin - Clavulanate Potassium (4:1))

Adult dose

Adults and children over 12 years old or weighing more than 40 kg: Administer Amoxicillin/Clavulanate potassium 250 mg/125 mg once, orally, three times a day every 8 hours. In cases of severe and respiratory infections, the dosage can be increased to 500 mg/125 mg once. In cases of renal impairment, the dosage is adjusted according to creatinine clearance. - Creatinine clearance 10 - 30 mL/min: Administer 250 - 500 mg of Amoxicillin every 12 hours.

Child dose

Children over 12 years old or weighing more than 40 kg follow the same dosage as adults. Children with renal impairment should have their dosages adjusted in the same manner.

This drug, as a beta-lactam antibiotic, should not be used in patients with a history of hypersensitivity to penicillin-based drugs. It is contraindicated especially in patients with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock. Caution is advised in patients with concurrent viral infections such as infectious mononucleosis or lymphocytic leukemia, as there may be an increased risk of rash. Patients with a history of liver dysfunction or jaundice may have a recurrence risk when taking this drug, and it is advisable not to use it. In patients with liver impairment, careful use is necessary as liver function may deteriorate, and those with moderate or severe renal impairment should adjust the administration interval to prevent excessively high blood concentrations. Caution is needed for patients with allergic tendencies or symptoms like bronchial asthma, rashes, or hives. For patients who have difficulty taking orally, those in poor nutritional status, or elderly patients, careful use is required to prevent bleeding risks due to vitamin K deficiency. In cases of gastrointestinal diseases with vomiting or diarrhea, sufficient drug absorption may not occur. This drug may cause various gastrointestinal side effects such as indigestion, diarrhea, vomiting, and abdominal pain, so if symptoms are severe, immediate discontinuation and consultation with a physician are mandatory. Symptoms of liver dysfunction may also occur, particularly in older adults over 60 years and men. Severe skin reactions such as skin rashes, hives, and in severe cases Stevens-Johnson syndrome may occur; if abnormal symptoms arise, immediate discontinuation of the drug is necessary. Hematological side effects such as leukopenia, thrombocytopenia, and anemia have been rarely reported, and neurological abnormalities may occasionally occur, such as headache, seizures, or confusion. Renal function may rapidly deteriorate, so patients with kidney disease require regular check-ups. The balance of intestinal flora may be disrupted, which may lead to infections like candidiasis or stomatitis. The tendency for bleeding due to vitamin K deficiency and symptoms of vitamin B complex deficiency may also rarely occur, necessitating caution during prolonged use. This drug should only be used for the minimum required duration to prevent the emergence of resistant bacteria, and caution is required for patients with a history of hypersensitivity as serious allergic reactions may occur. Anaphylactic shock may occur, thus monitoring the patient is necessary after administration, and emergency measures should be prepared. If diarrhea occurs during or after antibiotic use, the possibility of pseudomembranous colitis should be considered, and the drug should be discontinued immediately with medical consultation. Long-term use may lead to the risk of resistant bacteria proliferation, so when used for more than 14 days, the patient's condition should be carefully monitored. This drug is excreted via the kidneys, so dosage adjustments are necessary for those with decreased renal function. It should be avoided during the first three months of pregnancy, and during breastfeeding, any adverse effects in infants should be monitored, leading to discontinuation if abnormal symptoms are noted. It is not recommended for children under 12 years or weighing less than 40 kg. In the elderly, adverse reactions may occur more frequently due to decreased physiological function, necessitating careful dosage adjustments and administration intervals. This drug may affect certain clinical test results, so it is important to inform medical personnel about its use during tests. In cases of overdose, symptoms such as vomiting, diarrhea, and abdominal pain may occur, and in severe cases, renal failure or seizures may arise, necessitating immediate visit to a medical facility. The storage condition should be in a dry place at or below 25 degrees Celsius to maintain the drug's effectiveness, and consultation with medical professionals is required for any interacting medications during use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reaction, high fever with severe rash, blisters, skin peeling, painful mucosa of mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by coughing + fever, breathing problems, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

• Diarrhea
• pseudomembranous colitis
• indigestion
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This drug should be kept in a tightly sealed container to prevent moisture, stored in a dry place at or below 25 degrees Celsius. Proper storage will help maintain the drug's effectiveness for a longer duration.

Appearance

White or almost white, oblong film-coated tablet

Package unit

60 tablets / PT[ (4 tablets/PT * 15) ]