Rexib 100 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient, and it may be administered regardless of meals. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take celecoxib 200 mg once daily, or 100 mg per dose twice daily. 2. Rheumatoid arthritis Take celecoxib 100 mg or 200 mg per dose twice daily. 3. Ankylosing spondylitis (AS) Administer celecoxib 200 mg once daily, or 100 mg per dose twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks on 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50 % of the recommended daily dose.

This medication is primarily used as a non-steroidal anti-inflammatory drug for reducing inflammation and alleviating pain. Before taking this medication, you must consult with a doctor or pharmacist if you regularly consume more than three glasses of alcohol daily. This is essential as excessive drinking while taking this medication can lead to severe issues such as gastrointestinal bleeding. Additionally, this medication may increase the risk of cardiovascular diseases. There is an increased risk of serious thrombotic conditions such as myocardial infarction or stroke, thus it is important to use the lowest effective dose for the shortest duration possible. Monitoring for cardiovascular symptoms is crucial, and immediate action should be taken if symptoms like chest pain or shortness of breath occur. This medication can also affect the gastrointestinal system. There are risks of gastrointestinal perforation, ulcers, and bleeding, especially in elderly patients or those with a history of gastrointestinal diseases. If symptoms like epigastric pain, dyspepsia, black stools, or hematemesis occur while taking this medication, you should consult a healthcare professional immediately. This medication can impact liver and kidney function, so it should be used cautiously in patients with liver or kidney disease or a history thereof. Pregnant or potentially pregnant women, nursing mothers, patients with specific heart diseases, or those with severe liver or kidney impairment should avoid taking this medication. While taking this medication, various side effects such as headaches, dizziness, dyspepsia, edema, skin rashes, and elevated blood pressure may occur, so report any unusual symptoms to healthcare professionals. This medication may interact with other drugs; therefore, inform your doctor or pharmacist about any medications you are currently taking. Particular caution is necessary when taken with antihypertensive medications, anticoagulants, or some antidepressants and antibiotics. Regular blood tests and liver and kidney function checks are important while taking this medication to monitor health status. Dizziness or drowsiness may occur, so avoid driving or operating dangerous machinery. This medication can affect the fetus during pregnancy, so women who are pregnant or planning to become pregnant should avoid taking it, and if pregnancy is confirmed while on this medication, it should be discontinued immediately. In the case of breastfeeding, this medication can be passed into breast milk, so decide whether to continue breastfeeding or take the medicine after consulting a healthcare professional. This medication is not recommended for children and adolescents under 18 as safety and efficacy have not been established. Elderly patients may experience decreased liver, kidney, or heart function, requiring special attention and monitoring while using this medication. Store this medication in a tightly closed container, keeping it out of reach of children, and do not transfer it to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, increased liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, headache, leg cramps, sensory loss, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, ageusia, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, decreased appetite, increased appetite, depression, neuroirritability, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infections, sinusitis, pharyngitis, rhinitis, bronchitis, bronchospasm, exacerbation of bronchospasm, dyspnea, laryngitis, pneumonia, nosebleeds, voice disorder, vesicular dermatitis, dermatitis, nail disease, photosensitivity reactions, pruritus, erythematous rash, maculopapular rash, skin diseases, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash, arrhythmia, ventricular hypertrophy, angina, unstable angina, coronary artery disorders, myocardial infarction, heart failure, palpitations, tachycardia, stroke, aortic valve insufficiency, hematoma, asystole, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, intracerebral hemorrhage, single lesion, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, ear pain, hearing impairment, liver dysfunction, increased ALT, increased AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased blood sodium, increased blood potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, osteopathy, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, vasculitis, contact dermatitis, injection site reactions, skin nodules, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infections, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reaction, hallucinations, intracerebral hemorrhage, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, bile stasis, bile stasis hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease.

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, the medication is best stored at room temperature, between 1°C and 30°C, avoiding extremes of heat and cold.

Appearance

White, round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle