Moxiclen Tablets 375 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

Adults are to take 250 mg/125 mg orally three times a day, every 8 hours. In cases of severe and respiratory infections, the dosage can be increased to 500 mg/125 mg per dose. For patients with renal impairment, the dosage should be adjusted according to creatinine clearance: - Creatinine clearance above 30 mL/min: No dosage adjustment needed - 10 to 30 mL/min: 250 mg/125 mg or 500 mg/125 mg every 12 hours

Child dose

Children aged 12 or older or weighing over 40 kg are administered the same as adults, 250 mg/125 mg orally three times a day, every 8 hours. In cases of renal impairment, dosage should be reduced in the same manner as adults.

This medication should not be used in patients who have had specific allergic reactions. Especially for those who have had hypersensitivity reactions to penicillin or beta-lactam antibiotics, taking this medication can lead to severe allergic symptoms. Patients with viral diseases such as infectious mononucleosis or lymphocytic leukemia are at a higher risk of developing rashes and should be cautious. Additionally, patients who have previously experienced hepatic dysfunction or jaundice due to this medication or penicillin-type drugs should not use it due to the risk of recurrence. Patients with impaired liver function may experience worsening liver function while using this medication, requiring careful monitoring. In patients with moderate to severe kidney impairment, the medication may remain in the body longer and cause side effects, so dosage intervals should be adjusted. Those with allergic tendencies or symptoms like asthma, skin rashes, urticaria may experience allergic reactions more easily while taking this medication. Patients with gastrointestinal symptoms such as vomiting or diarrhea should be cautious as the medication may not be absorbed properly. Taking this medication may cause gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, or vomiting, and in rare cases, gastritis or pancreatitis may occur. If severe diarrhea or abdominal pain develops, the medication should be stopped immediately, and a doctor should be consulted. Symptoms of liver dysfunction may also occur, particularly in the elderly or males, and may appear late during or after treatment. If liver function is impaired, the medication should be discontinued. Skin itching or rashes may occur, and in severe cases, serious skin reactions such as Stevens-Johnson syndrome may occur. If any skin symptoms develop, the medication should be stopped immediately, and a doctor should be consulted. Blood-related irregularities such as leukopenia, thrombocytopenia, or anemia have been rarely reported in blood tests, and bleeding tendencies may occur. If any abnormal symptoms arise, consult a doctor. Central nervous system symptoms such as anxiety, drowsiness, headache, or seizures may rarely occur, and caution is needed, especially in patients with poor kidney function or in those taking high doses. Acute kidney damage may occur, so kidney function should be regularly monitored, and if abnormalities are found, the medication should be discontinued. This medication can affect intestinal bacterial balance, potentially leading to fungal infections like stomatitis or candidiasis. If symptoms develop, consult a doctor. Bleeding tendencies due to vitamin K deficiency may appear, so if bleeding symptoms occur, they should be reported immediately for appropriate treatment. Women who are pregnant or possibly pregnant are advised not to use this medication, especially during early pregnancy, and caution is needed while breastfeeding due to potential side effects in infants. This medication is recommended only for children over 12 years or those weighing more than 40 kg, and the elderly should have dosage adjustments and monitoring due to higher risks of side effects from impaired kidney and liver function. While taking this medication, there may be interactions with other drugs, so especially if taking anticoagulants, certain antibiotics, or anti-inflammatory drugs, consultation with a doctor or pharmacist is essential. In case of overdose, gastrointestinal symptoms, kidney function abnormalities, and neurological symptoms may appear, so the medication should be stopped immediately, and medical help should be sought. This medication should be stored in a dry container to prevent moisture, and during storage, a cool temperature between 1 and 25 degrees Celsius should be maintained. It is crucial to avoid direct sunlight, keep it away from damp places or excessively hot areas.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rashes with high fever, blistering, skin peeling, pain in oral/ocular mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, changes in skin or eyes to a yellowish color, extreme lethargy, liver abnormalities (jaundice), sudden and severe headache

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• appetite loss

This medication should be stored in a tightly sealed container to prevent moisture, maintaining a cool temperature between 1 and 25 degrees Celsius during storage. It is important to avoid direct sunlight and not to place it in humid or excessively hot areas.

Appearance

White or almost white oval film-coated tablet

Package unit

For domestic use - 100 tablets/box [100 tablets (10 tablets/PTP x 10)]