Orlistat Capsule 120 mg (Orlistat)

Adult dose

The recommended dose of this medicine is 120 mg of orlistat orally 3 times daily, taken with a fat-containing meal or within 1 hour after a meal. Patients should continue a nutritionally balanced, mildly hypocaloric diet in which approximately 30 % of calories are derived from fat. Daily intake of fat, carbohydrates, and protein should be distributed evenly among three meals. This medicine may be omitted if a meal is skipped or contains no fat. Because this medicine may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before this medicine or at least 2 hours after it, such as at bedtime. Taking more than 120 mg per dose, 3 times daily, does not increase the effectiveness of this medicine. Based on measurements of fecal fat, the effect of this medicine appears 24 ∼ 48 hours after taking the medicine. After treatment is discontinued, fecal fat content usually returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this medicine have not been evaluated for periods exceeding 4 years. Studies have not been conducted in patients with hepatic and/or renal impairment or older adults.

Child dose

Studies have not been conducted in children under 12 years of age.

This medication should not be used in patients with chronic malabsorption syndrome or cholestasis. Additionally, it should not be taken by patients who are allergic to this medicine or its components, pregnant or potentially pregnant women, and nursing mothers. Liver damage has been reported rarely, so any signs of liver dysfunction should be reported to a physician immediately, and this medication should be discontinued. It is important to monitor liver enzyme levels through liver function tests. Patients with hyperoxaluria or calcium oxalate nephrolithiasis should use this medication with caution. Use of this medication may affect the gastrointestinal tract, with symptoms such as abdominal distension, flatus, constipation, and oily stools frequently occurring. These symptoms are usually mild and transient and often occur within 3 months of starting treatment. However, in some patients, symptoms may persist for more than 6 months. This medication may reduce the absorption of fat-soluble vitamins and beta-carotene, so it is recommended to take vitamin supplements. Vitamin supplements should be taken at least 2 hours before or after taking this medication. If symptoms of liver dysfunction (loss of appetite, itching, jaundice, dark urine, pale stools, upper abdominal pain) occur while taking this medication, medical personnel must be notified immediately, and this medication should be stopped. Taking this medication with a high-fat meal may increase gastrointestinal side effects, so it is advisable to distribute daily fat intake evenly across three meals. If taken with oral anticoagulants, blood coagulation parameters should be checked regularly, and it is advisable not to take it with cyclosporine. This medication is not recommended for children under 12 years of age, and there is insufficient clinical data regarding the elderly. In cases of overdose, observation for 24 hours is needed, and generally, the action of this medication recovers quickly. Finally, this medication should be stored out of the reach of children and protected from light and moisture.

• Fatty stools
• abdominal bloating and flatulence
• increased frequency of stools
• fatty/greasy stools
• fecal urgency
• fecal incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea
• rectal pain/discomfort

This medication should be stored in a tightly closed container to protect it from air, light, and moisture. It is recommended to store it in a cool place at temperatures below 25 degrees Celsius.

Appearance

A hard capsule with upper and lower teal colors containing white or whitish powder or granules

Package unit

30 capsules/bottle, 300 capsules/bottle