Lova Tablet 20 Milligrams (Rosuvastatin Calcium)

Adult dosage

The initial dosage is 5 milligrams once daily, and if greater reduction in LDL cholesterol is needed, the maintenance dose may be adjusted. The maintenance dose is generally 10 milligrams once daily for most patients. The maintenance dose should be appropriately adjusted every 4 weeks or longer based on the LDL cholesterol levels, treatment goals, and patient response, and may be increased up to a maximum of 20 milligrams per day.

Children's dosage

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17) is 5 milligrams to 20 milligrams once daily. The administration dosage should be adjusted according to the recommended therapeutic goals for each individual patient.

This medication should not be administered to certain patients. For instance, it should not be given to patients who are allergic to this medication, have severely impaired liver function, have muscular diseases, have significantly reduced kidney function, or are pregnant or breastfeeding women. Additionally, high doses of this medication are contraindicated in patients at high risk for muscle damage, and in such cases, the dosage should be adjusted or avoided. This medication contains lactose and should not be taken by patients with lactose intolerance. Regular liver function tests are important before starting and during treatment with this medication. Patients with a history of liver disease or excessive alcohol consumption should be particularly cautious. If symptoms such as myalgia, muscle weakness, fatigue, and fever occur, they should immediately inform their doctor, and muscle enzyme tests should be performed if necessary to check for muscle damage. This medication can rarely cause serious skin reactions or liver damage, so if a rash, jaundice, or severe itching occurs, it must be discontinued immediately, and a healthcare provider should be consulted. Drug interactions may occur when taken with other medications, so any current medications should be disclosed to healthcare providers. Caution is advised when taken with specific antiviral drugs, immunosuppressants, antifungals, antibiotics, and fibrate medications. Women of childbearing potential should use appropriate contraception while taking this medication, and should discontinue it immediately if pregnancy is confirmed. In case of overdose, there is no specific antidote, so appropriate treatment and monitoring of liver function and muscle enzymes according to symptoms is necessary. This medication does not appear to have a significant impact on the ability to drive or operate machinery; however, caution is advised as dizziness may occur. This medication may show higher systemic exposure in Asian patients, so dose adjustment may be necessary.

Serious side effects

• Rash, hypersensitivity reactions including angioedema, severe allergic reactions
• Severe skin adverse reactions including severe rash with fever, blistering, skin peeling, oral/ocular mucosal pain (Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms)
• Respiratory issues such as dyspnea and cough
• Yellow discoloration of the skin or eyes (jaundice), hepatitis, liver failure
• Sudden and severe headache, seizures, altered consciousness

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• thrombocytopenia
• diarrhea

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to store it at room temperature between 1 and 30 degrees Celsius, away from extreme heat or cold.

Appearance

Pink, round, film-coated tablets

Package unit

PTP packaging - 30 tablets/PTP [30 tablets (15 tablets/PTP × 2)]