Sereco One Capsule 200 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted according to the patient and may be administered without regard to meals. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg per dose twice daily. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg per dose twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg per dose twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment option should be considered. Acute pain and primary dysmenorrhea: The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may increase the risk of gastrointestinal bleeding in individuals who regularly consume more than three alcoholic drinks a day, so it should only be taken after consulting a doctor or pharmacist. This medication may increase the risk of serious cardiovascular adverse reactions such as thromboembolism, myocardial infarction, and stroke, so it should be used at the lowest possible dose for the shortest duration, and immediate medical attention should be sought if cardiovascular symptoms occur. There is a risk of serious gastrointestinal adverse reactions such as gastrointestinal perforation, ulcer, and bleeding, so those with a history of gastrointestinal disease or the elderly should be especially cautious and seek medical attention immediately if symptoms such as epigastric pain, black stools, or vomiting blood occur. This medication should not be administered to patients with certain drugs or diseases, including severe liver dysfunction, renal dysfunction, active gastric ulcer, heart failure, or women who are pregnant or breastfeeding. Patients with impaired liver or kidney function, asthma, hypertension, a history of cardiovascular diseases, and the elderly should use this drug cautiously and require regular monitoring. This medication can cause various adverse reactions, common symptoms include dyspepsia, headache, dizziness, hypertension, edema, rash, and if severe skin rash or allergic reactions occur, the drug should be discontinued immediately. This medication can affect liver and kidney function, so periodic blood tests and liver and kidney function assessments are needed to confirm any abnormalities. This medication has many drug interactions, and if other medications are being taken, it is essential to consult healthcare professionals, especially cautious if used in conjunction with blood pressure medications, anticoagulants, diuretics, and antidepressants. Women who are pregnant or planning to become pregnant should avoid taking this medication, and breastfeeding women should consult healthcare professionals before taking this medication as it may require stopping breastfeeding. It is not advisable to use this medication in children and adolescents as safety and efficacy have not been established. The elderly are likely to have decreased liver and kidney function, so they need to be more careful when taking this medication, and it is recommended to start with a low dose if body weight is low. Dizziness or drowsiness may occur during medication, so it is advisable to avoid driving or operating machinery. This medication does not affect platelet function and cannot be used as a substitute for aspirin in the prevention of cardiovascular disease. The risk of gastrointestinal bleeding may increase when used with aspirin. If this medication is used for a long time, it is important to receive regular blood tests and liver and kidney function assessments, and immediate consultation with healthcare professionals is necessary if any abnormal symptoms occur.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, indigestion, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, dysgeusia, albuminuria, cystitis, hematuria, dysuria, frequency of urination, nephrolithiasis, urinary incontinence, urinary tract infection, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine occult blood, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, headache, leg cramps, tension, sensory decline, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, back pain, allergic exacerbation, allergic reaction, weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, anorexia, increased appetite, depression, neuroexcitability, sleepiness, fatal intracranial hemorrhage, hallucinations, seizure exacerbation, upper respiratory tract infection, herpes simplex, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased serum sodium, increased serum potassium, elevated BUN, elevated CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, elevated alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical muscle tension, synovitis, tendinitis, myositis, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pneumonia, contact dermatitis, injection site reactions, skin nodules, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, menstrual disorders, female infertility, chest pain, anaphylaxis reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis

This drug should be stored in a tightly sealed container to prevent air and moisture from entering, and it is best kept in a cool place between 15 to 30 degrees Celsius.

Appearance

A capsule with white to slightly yellow powder filled, with a white upper and lower shell.

Package unit

30 capsules/bottle, 100 capsules/bottle