Donepezil 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. If bizarre dreams, nightmares, or insomnia occur, considering morning dosage may be an option. The concentration of donepezil reaches a steady state after 15 days of administration, so a dosage of 5 mg should be administered for 4 to 6 weeks. After clinical response evaluation, it can be increased to 10 mg, and caution should be taken regarding gastrointestinal adverse reactions when increasing the dosage to 10 mg per day. Patients with low body weight aged 85 and older should be monitored carefully as adverse reactions are more frequent, and low-weight elderly women should not exceed 5 mg per day.

Child dose

There is no experience in using this medication in pediatric patients.

This medication contains Donepezil Hydrochloride as the active ingredient and is used for the treatment of symptoms of Alzheimer's type dementia. This medication should not be administered to patients who are allergic to Donepezil Hydrochloride, piperidine derivatives, or any other components of this medication. Pregnant women, women who may become pregnant, and breastfeeding women should not take this medication. This medication contains lactose; therefore, patients with lactose intolerance or congenital lactose enzyme deficiency should avoid taking it. Patients with heart disease or cardiac conduction disorders should use this medication cautiously as it may slow down heart rate or cause arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious as there may be a risk of gastrointestinal bleeding or ulcer exacerbation. Patients with asthma or obstructive pulmonary disease should be careful as bronchospasm or increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should also be careful as this medication may worsen symptoms. This medication contains Yellow No. 5, and patients with hypersensitivity to this ingredient should be cautious. During the usage of this medication, abnormal cardiac reactions such as syncope, bradycardia, heart block, myocardial infarction, or heart failure may occur, and if any abnormal symptoms appear, immediate consultation with a healthcare provider is necessary. Gastrointestinal abnormalities such as peptic ulcers, gastrointestinal bleeding, nausea, vomiting, diarrhea may occur, and attention should also be given to liver dysfunctions or symptoms of jaundice. Neurological abnormalities such as seizures, intracerebral hemorrhage, movement disorders, tremors, and walking difficulties may appear. Severe adverse reactions such as respiratory distress, acute pancreatitis, acute renal failure, and sudden death have also been reported, so immediate treatment is required if symptoms occur. During treatment, patients' conditions should be regularly monitored, and appropriate measures should be taken in case of adverse reactions. This medication may affect driving or operating machinery, so attention is needed, especially at the beginning of treatment or with dosage adjustments. Since this medication can interact with other drugs, especially cardiac medications, antibiotics, antidepressants, antipsychotics, and anti-inflammatory drugs, consultation with a physician or pharmacist is essential when using them concurrently. It is principled that pregnant or breastfeeding women should not take this medication; if absolutely necessary, they should use it after consulting a specialist. The safety for pediatric patients has not been established; therefore, it is not administered to children. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, sweating, and respiratory depression may occur, so immediate medical treatment is required. This medication should be stored out of the reach of children and not transferred to other containers.

Serious side effects

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcers
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Loss of appetite, insomnia, drowsiness, dizziness, headache, fatigue, nausea, vomiting, diarrhea, constipation, abdominal pain, rash, itching, muscle pain, urinary incontinence, frequent urination, thrombocytopenia
• Hallucinations, agitation, aggressive behavior, anxiety, drowsiness, delusions, confusion, depression, insomnia, tremors, walking difficulties, involuntary movements, decreased concentration, mental sluggishness, sweating, increased blood pressure, palpitations, hypotension, hypertension, atrial fibrillation, heart block, sinoatrial block, atrioventricular block

This medication should be stored in a tightly sealed container to prevent air from entering and kept at room temperature between 1 to 30 degrees Celsius. This will help maintain the medication's effectiveness over time.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle