Anticran Tablet 625 mg (Amoxicillin · Clavulanate Potassium)

Adult dose

Adults and children 12 years and older or weighing 40 kg or more: Amoxicillin / Clavulanate Potassium at a single dose of 250 mg/125 mg, taken orally three times a day at eight-hour intervals; in cases of severe and respiratory infections, the dose can be increased to 500 mg/125 mg per single dose. In cases of renal impairment, the dosing should be adjusted according to the creatinine clearance as follows: - Creatinine clearance 10 to 30 mL/min: Amoxicillin dose of 250 mg to 500 mg taken orally every 12 hours. 10 mL/min or less: Amoxicillin dose of 250 mg taken orally every 24 hours, ensuring not to exceed the maximum dose. - In children: adjust the dose by the same method. ○ However, for dental infections, the Amoxicillin dose is 250 mg taken orally three times a day for five days.

Child dose

In children under 12 years of age or weighing less than 40 kg, the dose should be adjusted according to the creatinine clearance as in adults.

This medication is a penicillin-class antibiotic and should not be administered to certain patients. Firstly, patients with a severe allergic reaction to the ingredients of this medicine or beta-lactam antibiotics may be at risk if they use this medicine. Additionally, patients suffering from viral infections such as mononucleosis or lymphocytic leukemia are at higher risk of side effects such as rashes. It is advisable to avoid use in patients who have previously experienced liver dysfunction or jaundice due to this medication or penicillin-class drugs, as the risk of recurrence exists. Patients with impaired liver function should use it with caution as liver function may worsen. In patients with severe kidney impairment, the drug may remain in the body for a prolonged period, which can lead to side effects, so the dosing intervals must be adjusted. Those with allergic constitution or frequent bronchial asthma, skin rashes, etc., should also be cautious. Moreover, patients who have difficulty in oral intake, elderly patients, or those with poor systemic condition may be at risk of bleeding due to vitamin K deficiency. In patients with gastrointestinal diseases experiencing severe vomiting or diarrhea, the absorption of the drug may not be sufficient. While taking this medicine, gastrointestinal symptoms such as diarrhea, vomiting, abdominal pain, and loss of appetite may occur; in severe cases, serious enteritis such as pseudomembranous colitis may develop. If such symptoms occur, the medication should be discontinued immediately, and a doctor should be consulted. Liver function abnormalities may also occur rarely, especially in the elderly or males, and symptoms of hepatitis or jaundice may arise. Severe hypersensitivity reactions may manifest as itching or severe rash, blisters, and mucosal damage, and upon such symptoms, the use should be discontinued immediately, following the physician's instructions. Rare reports of blood-related abnormalities such as leukopenia, anemia, and thrombocytopenia might require regular blood tests. The drug may affect the central nervous system, possibly leading to anxiety, drowsiness, headaches, and rarely seizures, so consultation with healthcare providers should be sought if abnormalities occur. Regular kidney function tests are recommended as kidney function may be impaired. This medicine may interact with other drugs, so if you are taking anticoagulants, other antibiotics, anti-inflammatories, or oral contraceptives, it is essential to inform your doctor or pharmacist. Women who are pregnant or breastfeeding should carefully decide on the use of this medicine as it may affect the fetus or infant, especially during the first trimester of pregnancy, it is advisable to avoid use. The use is not recommended for children under 12 years of age or weighing less than 40 kg due to limited experience. Elderly patients may exhibit adverse reactions more readily due to declining bodily functions, hence dosage and interval should be adjusted, with careful monitoring. During the administration of this medicine, it is important to regularly check liver and kidney function, as well as blood status, to detect any abnormalities. In case of overdose, gastrointestinal symptoms and kidney damage may occur, so it is vital to adhere strictly to the prescribed dose and consult healthcare providers immediately if any abnormal symptoms arise.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, mucosal pain in mouth/eyes, yellowing of skin or eyes (jaundice), extreme lethargy throughout the body, sudden and very severe headaches, thunderclap headaches, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output, severe swelling throughout the body coupled with increased blood pressure, anaphylaxis.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medicine should be stored in a sealed container to prevent moisture absorption and kept in a dry place at temperatures below 25 degrees Celsius. Caution is needed as the effectiveness of the medication may decrease in high humidity or heat conditions.

Appearance

White or nearly white oval film-coated tablets

Package unit

40 tablets/PTP [(4 tablets/PTP) x 10], 60 tablets/PTP [(6 tablets/PTP) x 10]