Megasimba Tablet 10/10 mg

Adult dose

This drug is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dosage range is 10/10mg to 10/40mg daily, with a typical initial dose of 10/20mg daily. Patients with lesser needs for LDL cholesterol reduction may begin with 10/10mg daily. Patients with homozygous familial hypercholesterolemia should take 10/40mg once daily in the evening.

This drug may cause muscular disorders such as myopathy or rhabdomyolysis. The risk may be higher when taking high doses or in conjunction with certain other medications. Those allergic to any ingredients of this drug or who have active liver disease or persistently elevated liver enzyme levels of unknown origin should not take this medication. Women who are pregnant or breastfeeding should not take this drug, and those planning to become pregnant should consult with a physician. This drug should not be combined with medications that inhibit the CYP3A4 enzyme, such as certain potent antifungals, antibiotics, and antiviral drugs, as it increases the risk of muscle damage. Moreover, it should not be used with medications such as gemfibrozil, cyclosporine, and danazol. While taking this medication, if muscle pain, muscle weakness, or unexplained muscle pain occurs, you should immediately notify your doctor, who may check for muscle damage through blood tests if needed. Patients with liver function disorders should have regular liver function tests before and during the use of this drug, and should discontinue use if liver function worsens. This drug has not been sufficiently studied for safety and efficacy in children and adolescents, especially girls under 10 years old or before menstruation, so caution is needed. Elderly patients may also be sensitive to this medication, so careful administration is necessary, and potential interactions with other drugs should always be considered. During the course of taking this drug, it is advisable to inform the doctor or pharmacist whenever starting a new medication and to limit the intake of certain foods such as grapefruit juice.

Serious side effects

Myopathy, rhabdomyolysis, angioedema, rash, pancreatitis, cholelithiasis, cholecystitis, anaphylaxis, lupus-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, eosinophilia, arthritis, arthralgia, urticaria, photosensitivity, fever, chills, flushing, malaise, dyspnea, toxic epidermal necrolysis (Lyell's syndrome), mucocutaneous syndrome (Stevens-Johnson syndrome)

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• muscle pain
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This drug should be stored in a tightly closed container to prevent exposure to air and moisture, preferably at room temperature between 1 degrees and 30 degrees Celsius. This storage method will help maintain the efficacy of the drug for a longer period.

Appearance

White to light yellow, bilaterally convex rectangular tablet

Package unit

30 tablets (10 tablets/PTP × 3)