Donepezil Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. If strange dreams, nightmares, or sleep disturbances occur, morning administration of this medication may be considered. The concentration of donepezil reaches a steady state 15 days after administration, and the frequency of adverse reactions may be influenced by the rate of increase, so continue administering the 5 mg dosage for 4 to 6 weeks. Evaluate clinical responses during this period.

Child dose

There is no experience in using this medication in children.

This medication, which contains donepezil hydrochloride as its active ingredient, is mainly used for improving symptoms of Alzheimer's type dementia. This medication should not be administered to certain patients. For example, individuals who are allergic to this medication or its components, pregnant women or those who may become pregnant, and people with lactose intolerance or specific genetic diseases should not use this medication. Patients with heart disease or heart conduction disorders, those with a history of peptic ulcers or currently taking nonsteroidal anti-inflammatory drugs, patients with asthma or obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease should use this medication with caution. While taking this medication, various adverse reactions may occur, so caution is necessary. Cardiac-related issues such as bradycardia, heart block, and myocardial infarction may arise, and gastrointestinal issues may include gastric ulcers, bleeding, nausea, vomiting, etc. There have also been reports of severe adverse reactions such as liver dysfunction, cerebrovascular problems, seizures, myalgia, respiratory difficulties, acute pancreatitis, and renal failure. In the central nervous system, symptoms such as hallucinations, anxiety, insomnia, drowsiness, depression, confusion, muscle cramps, or movement disorders may occur. This medication should be used under the supervision of a physician experienced in dementia treatment, and the therapeutic effects and side effects should be evaluated regularly. If there is no therapeutic effect or if side effects are severe, consideration should be given to discontinuing use. Patients with cardiovascular disease may experience arrhythmias while taking this medication, and an electrocardiogram may be necessary. This medication can increase gastric acid secretion and promote gastrointestinal motility, so patients with a history of peptic ulcers should carefully monitor for symptom exacerbation. It may affect the ability to drive or operate machinery, so caution is needed at the beginning of treatment or when changing the dosage. It is safe for pregnant or breastfeeding women to avoid using this medication, and it should only be decided after consulting a specialist if absolutely necessary. Safety in children has not been established, so its use is not recommended. This medication is primarily metabolized in the liver, so caution is necessary when using it with drugs that affect CYP3A4 and CYP2D6 enzymes. Concurrent use with certain antibiotics, antidepressants, antiarrhythmics, etc., may increase the risk of cardiac rhythm disturbances. In the case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may occur, necessitating immediate medical treatment, and an antidote like atropine may be used. This medication should be stored out of reach of children, and transferring it to another container should be avoided as it can lead to a decrease in quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanying cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination problems

Mild side effects

• Nausea
• vomiting
• diarrhea
• appetite loss
• insomnia
• headache
• dizziness
• drowsiness
• fatigue
• fever

This medication should be stored in a sealed container to prevent air from entering and should be kept at a temperature between 1 degree and 30 degrees Celsius at room temperature. This way of storage can maintain the medication's effectiveness and prevent deterioration.

Appearance

This medication is a white, round, film-coated tablet.

Package unit

30 tablets/bottle