Danaril Tablet (Glymepiride)

Adult dose

This medication is taken orally once daily, preferably before breakfast or immediately before the first meal, with more than 1/2 cup of water, without chewing. The initial dose is 1 mg of glymepiride taken once daily, and can be increased by 1 mg at intervals of 1-2 weeks. Generally, there is little additional effect when administered above 4 mg; however, some patients may increase to 6 mg or 8 mg. The usual dose is 4 mg per day.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or in coma. It should also be avoided in individuals with allergies to any ingredient included in this medication or similar medications. Patients with severely impaired liver or kidney function should not use this medication, and it is recommended to switch to insulin therapy in such cases. Women who are pregnant or may become pregnant and those who are breastfeeding should not take this medication. Patients with severe infections, undergoing surgery, or with severe trauma should use insulin therapy instead of this medication. When gastrointestinal disturbances such as diarrhea or vomiting occur, there is a risk of hypoglycemia due to poor absorption of food; hence caution should be exercised. Patients with genetic conditions like lactose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take this medication. The risk of hypoglycemia is high during the initial week of treatment, so blood glucose should be checked frequently and monitored closely. Elderly individuals, malnourished patients, those skipping meals, patients consuming large amounts of alcohol, and those with compromised liver or kidney function are at higher risk for hypoglycemia. When taking with other medications, consultation with a doctor or pharmacist is necessary, as interactions may impact blood glucose control. In case of hypoglycemic symptoms, immediately ingest food containing sugar to alleviate symptoms; in severe cases, seek medical assistance. Serious side effects such as liver function anomalies, blood disorders, and allergic reactions may occur; report any unusual symptoms to a doctor immediately. During treatment with this medication, maintaining a regular diet, exercise, and weight control is crucial, as is undergoing regular blood glucose and urine sugar tests. Pregnant or breastfeeding women should not take this medication and should switch to insulin therapy if necessary. In case of overdose, severe hypoglycemia may occur, requiring immediate hospitalization and treatment, such as inducing vomiting, administering activated charcoal, or glucose injection. This medication is not recommended for children as its safety and efficacy have not been established in pediatric populations.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash accompanied by fever, blisters, peeling of skin, pain in mucous membranes of mouth/eyes, shortness of breath or breathing difficulty, asthma attack, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or initiative

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Also, to maintain its effectiveness, it is best to store it at a temperature between 1°C and 30°C.

Appearance

Green, oblong tablet

Package unit

30 tablets/bottle, 300 tablets/bottle