Megaglime Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day before meals or with meals. The dosage may be adjusted considering each patient's current therapy, efficacy, and tolerability, which requires appropriate blood sugar monitoring. Normally, treatment is initiated with a low dose, and the dosage can be adjusted based on the patient's current medication and blood sugar levels. In clinical trials, the initial daily dose was Glimepiride/Metformin Hydrochloride 2 mg/500 mg.

This medication can cause severe lactic acidosis or hypoglycemia, especially when there is a rapid decline in kidney function. It is advisable to temporarily discontinue this medication and consult a doctor in the case of dehydration. Caution is also needed when used with other medications that may affect kidney function. Due to the potential increase in cardiovascular mortality, it is important to fully understand the risks and benefits of this medication in conjunction with other treatments. It should not be administered to patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver or kidney dysfunction, or to pregnant or breastfeeding women. The risk of hypoglycemia is higher during the initial dosing phase, so special caution is required for patients with poor nutritional status, irregular eating patterns, excessive alcohol consumption, or weakened kidney or liver function. Gastrointestinal symptoms such as diarrhea, nausea, and vomiting may occur when taking this medication, usually temporarily at first. However, if these symptoms are severe or persistent, consultation with a physician is necessary. Allergic reactions may occur, so it is essential to inform medical personnel immediately if symptoms such as hives or breathing difficulties arise. Hematological anomalies and vitamin B12 deficiency may occur, hence regular blood tests and monitoring of vitamin B12 levels are necessary. As this medication is excreted through the kidneys, kidney function should be monitored regularly, and treatment should be discontinued or dosage adjusted in subjects with decreased kidney function. Drug interactions may occur when used in combination with other medications, thus it is important to inform medical personnel of all medications being taken, and closely monitor blood sugar changes. It is advised not to use this medication during pregnancy or breastfeeding, and to consider switching to insulin therapy instead. Extra caution is required for children and the elderly; particularly, dosage adjustment and monitoring are crucial for elderly patients due to reduced kidney function. In case of overdose, severe side effects such as hypoglycemia or lactic acidosis may occur, requiring immediate medical treatment. While taking this medication, it is vital to maintain a regular diet and exercise, and to undergo routine blood sugar and kidney function tests. Caution is advisable during driving or operating machinery due to potential decreased alertness from hypoglycemia or hyperglycemia. Store this medication out of reach of children and avoid transferring it to a different container.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, hypotension or severe allergic reactions, severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, jaundice of skin or eyes, general malaise, liver abnormalities, sudden and severe headache, seizures, loss of consciousness, visual disturbances, paralysis, severe kidney issues.

Mild side effects

Nausea, vomiting, abdominal distension, loss of appetite, indigestion, constipation, abdominal pain, unpleasant metallic taste, visual impairment, erythema, itching, rash, diarrhea, abdominal swelling, palpitations, dizziness, hematological abnormalities (thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia), elevated liver enzymes, liver dysfunction (cholestasis, hepatitis), hepatitis, allergic vasculitis, skin photosensitivity.

This medication should be stored in a sealed container to prevent air entry, at a temperature between 1°C and 30°C. This helps maintain the effectiveness of the medication and prevents degradation.

Appearance

White, oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle