Pegot Tablet 40mg (Febuxostat)

Adult dosage

1. Adults Administer this medicine at a dose of 40mg or 80mg once daily, with or without food. This medicine acts very rapidly; therefore, recheck serum uric acid levels after 2 weeks. The treatment goal is to reduce and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child-Pugh class C).

This medication may increase the risk of cardiovascular death in patients with cardiovascular diseases; therefore, caution should be exercised in patients with a history of heart or cerebrovascular diseases. Patients with allergies to the active ingredient or excipients, those taking specific medications (mercaptopurine, azathioprine), and patients with genetic metabolic disorders like lactose intolerance should not take this medication. Patients with a history of liver disease or thyroid dysfunction should have regular tests of liver and thyroid function when administering this medication, and patients with impaired cardiac function should also use it cautiously. Various side effects such as liver dysfunction, diarrhea, headache, rash, fatigue, and dizziness may occur; therefore, consult with a healthcare professional if abnormal symptoms appear. Do not start this medication during an acute attack of gout and use appropriate treatment as gout symptoms may temporarily worsen at the beginning of treatment. This medication can interact with certain drugs, so it is essential to inform your healthcare provider about any other medications you are taking, particularly to avoid concurrent use with mercaptopurine and azathioprine. It is advisable for pregnant or breastfeeding women to refrain from taking this medication, and it is not recommended for children or adolescents under 18 years of age as there is no experience of use in this population. While no special dosage adjustment is required for the elderly, caution is advised as sensitivity may vary among individuals. If symptoms of liver dysfunction (weakness, loss of appetite, jaundice, etc.) occur during treatment with this medication, stop taking it immediately and inform a healthcare professional. Caution is needed as drowsiness or dizziness may occur when driving or operating dangerous machinery.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, cardiac murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of bloody stools, oral ulcers, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, mood disturbances, gait disturbances, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes insipidus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramping, muscle fasciculation, muscle spasm, muscle weakness, musculoskeletal pain, rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, incomplete paralysis, sensory loss, olfactory impairment, focal ischemic attacks, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attacks, tremors, restlessness, anxiety, depression, insomnia, excitability, decreased libido, neuroticism, panic attacks, personality changes, hematuria, nephrolithiasis, increased urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin necrosis, purpura, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin exfoliation, petechiae, photosensitivity, pruritus, purpura, skin discoloration, pigmentation changes, skin lesions, bromhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, bruise, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reactions, eosinophilia, drug reactions associated with systemic symptoms, fever, hematological disorders, renal disorders, liver disorders, liver failure, jaundice, hepatic impairment, liver function abnormalities, angioedema, agranulocytosis, rhabdomyolysis, increased CPK, chest pain, hepatic coma, cough, hearing loss, asthenia, fever, abdominal pain, diarrhea, malignant lung neoplasm, influenza-like symptoms, gastritis, gout, oliguria, pleural effusion, pruritic rash, hepatic coma, herpes simplex, fecal incontinence, dysuria, frequent bowel movements, tonsillitis, pleural effusion, allergic rhinitis, bone fracture, malignant lung neoplasm, peripheral artery obstructive disease

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. Additionally, it is best stored at room temperature between 1°C and 30°C. This storage method helps maintain the efficacy and safety of the medication.

Appearance

White to light yellow elongated film-coated tablets

Package unit

Domestic use - 30 tablets/bottle, exported - 30 tablets/PTP [(10 tablets/PTP * 3)]