Taliz Tablet 2.5 mg (mirogabalin besilate)

Adult dose

This drug is administered orally without regard to meals. Adults can typically start with a dose of 5 mg taken twice daily as an initial dose. Afterward, the dose can be gradually increased in increments of 5 mg at least one week apart, up to a maximum oral dose of 15 mg taken twice daily. Based on individual patients’ age and symptoms, the dose can be appropriately adjusted within a range of 10 mg to 15 mg per administration for twice daily dosing.

This medication should not be used in patients who are allergic to this drug or its components. In diabetic patients, this drug may cause weight gain, which may require adjustment of the dosage of blood sugar control medications. Patients with impaired kidney function, elderly individuals over 65 years, and women who are pregnant or breastfeeding should take special precautions when using this drug. Symptoms such as drowsiness, dizziness, and loss of consciousness may occur during the use of this drug. Careful observation is necessary during these symptoms, as there is a risk of falling. This drug may affect liver function, so liver health should be monitored regularly. If symptoms such as fatigue or reduced appetite occur, the medication should be discontinued immediately and medical consultation sought. Weight gain may occur, so attention should be paid to diet and exercise to prevent obesity, and it is advisable to monitor weight changes regularly. This drug does not treat the underlying causes of neuropathic pain; it should be used as an adjunct to the treatment of the root cause. Suddenly stopping the medication can result in withdrawal symptoms such as insomnia, nausea, diarrhea, and loss of appetite, so the dosage should be gradually reduced according to a doctor's instructions. Vision disturbances may occur, so if symptoms such as blurred vision or diplopia arise, the patient should inform a doctor and receive appropriate treatment. This drug may interact with other medications, so caution is especially needed when taken with probenecid, cimetidine, lorazepam, and alcohol. Women who are pregnant or may become pregnant should consider the potential effects on the fetus when taking this medication, and breastfeeding women should also carefully consider the decision to take it as the drug may be transmitted through breast milk. Elderly individuals have a higher risk of reduced kidney function, so dosage and administration intervals should be adjusted, and particular attention should be paid to the risk of falls due to dizziness or drowsiness. The safety for use in children has not been established, so it is best not to use it. In cases of overdose, symptoms such as headache, weakness, and joint swelling may occur, and appropriate treatment should be administered based on symptoms. This drug should be kept out of reach of children and stored in its original packaging, not transferred to other containers. Patients should be familiar with the method of taking the drug from the packaging to ensure safe administration.

Serious side effects

hives, swelling, liver function impairment (potential for increased liver enzymes and jaundice), symptoms of suspected severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor), severe skin adverse reactions (severe rash with fever, blisters, skin shedding, pain in mouth/eyes mucosa), respiratory problems (shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough+fever), severe renal impairment

Mild side effects

• drowsiness
• dizziness
• orthostatic dizziness
• insomnia
• headache
• tremor
• sensory impairment
• memory impairment
• amnesia
• speech disturbance

This drug may be sensitive to air or humidity, so it must be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1 and 30 degrees Celsius. Storing it this way ensures the drug's effectiveness is maintained safely.

Appearance

peach-colored round film-coated tablet

Package unit

100 tablets/[(10 tablets/PTP x 10) ]