Idizol Capsule 100 mg (Itraconazole)

Adult dosage

This medicine should preferably be administered immediately after a meal to increase absorption. The capsules must be swallowed whole. 1. Short-term treatment This medicine continues to have a therapeutic effect in skin tissue even after treatment is discontinued. Therefore, the final clinical and mycological response should preferably be assessed 2～4 weeks after completion of the prescribed treatment. 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Tinea versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week treatment-free period; this constitutes 1 cycle. Administer up to 2 cycles when only the fingernails are infected, and up to 3 cycles when the toenails are infected. Site of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without concomitant fingernail infection) Treatment No treatment Treatment No treatment Treatment Fingernails Treatment No treatment Treatment 2) Continuous therapy Administer 200 mg once daily for 3 months. After treatment ends, the therapeutic effect continues for 3 months in the fingernails and 6 months in the toenails. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this medicine may be reduced; if necessary, double the dose. Indication Dose Average duration of treatment1 Remarks Aspergillosis 200mg once daily 2~5 months For invasive or disseminated disease, increase the dose to 200mg twice daily Candidiasis 100~200mg once daily 3 weeks~7 months Cryptococcal meningitis 200mg twice daily 2 months~1 year Maintenance therapy (for AIDS patients only) : 200mg once daily2 Paracoccidioidomycosis 100mg once daily 6 months There are no efficacy data for this dosage regimen for the treatment of paracoccidioidomycosis in ADIS patients. 1 The duration of treatment should be adjusted according to clinical response. 2 The duration of treatment should depend on the status of immune recovery.

This medication may pose life-threatening risks for patients with impaired heart function, especially in cases of congestive heart failure, and should not be used unless for treatment of serious infections. If symptoms of heart failure occur during treatment, it should be immediately discontinued. Patients with hypersensitivity to this drug or reduced heart function, and those who are at increased risk when combining with certain medications, should not use this drug. Pregnant women or those who may become pregnant, as well as nursing mothers, should also avoid using this medication. Patients with hepatic dysfunction or a history of hepatotoxicity should undergo regular liver function tests during treatment with this drug and dosage adjustments may be necessary if needed. Patients with renal impairment should be monitored and adjust the dosage since the drug's absorption may change. Patients with weakened immune systems, such as those with AIDS or organ transplant recipients, should monitor drug responses and adjust dosages. This medication has numerous interactions with other drugs, which may exacerbate side effects based on the concomitant medications; hence consultation with healthcare professionals is essential. Caution should be taken when combined with heart-related drugs, anticoagulants, antineoplastics, antipsychotics, calcium channel blockers, etc. If abnormalities such as liver dysfunction, skin rash, allergic reactions, hearing loss, or neuropathy occur during the use of this drug, notify healthcare professionals immediately. When driving or operating machinery, be cautious as dizziness or visual disturbances may occur. This drug does not absorb well under low acidity, so taking it with acidic beverages may help if potassium-reducing medications are being used. There is no specific antidote for overdose, so appropriate treatment should be administered according to symptoms and this drug is not removed by hemodialysis. Keep this medication out of the reach of children and store it in its original container to prevent misuse or quality deterioration.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disturbance, sensory loss, sensory alteration, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, pruritus, rash, urticaria, polyuria, erectile dysfunction, menstrual disorder, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, altered mental status, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disorder, cough, gastrointestinal disorder, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal dysfunction, incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased blood urea, increased gamma-glutamyl transferase, increased liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, capillary edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular extrasystole, atrial block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal lumbar pain, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, decreased appetite, malaise, brown urine, increased liver enzyme levels, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Rehl syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein, positive urine glucose, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, increased serum triglyceride levels, burning sensation, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremor, visual impairment, transient hearing loss, permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase activity

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. Storing it this way can help maintain the drug's effectiveness for a long time.

Appearance

A hard capsule filled with white or grayish round pellets with a blue upper part and a pink lower part

Package unit

30 capsules/bottle, 100 capsules/bottle