Hymet Tablet 15/850 mg

Adult dosage

The dosage of this medication should be individualized based on efficacy and tolerability, not exceeding a combination of pioglitazone 30 mg and metformin 2500 mg. Initial dosage should be determined based on the patient's current treatment regimen. Start with one tablet daily and gradually adjust the dosage according to the treatment response. Patients transitioning from combination therapy of pioglitazone and metformin may start with the existing dosing.

This medication can cause severe lactic acidosis and hypoglycemia, so caution is needed especially in patients with impaired kidney function or heart disease. Lactic acidosis is a rare but very serious condition that can occur due to the accumulation of metformin in the body, and it can be fatal. This medication should not be administered to patients with liver dysfunction, dehydration, sepsis, or hypoxia, and if these conditions occur, medication should be stopped immediately. Patients with heart failure, especially those with severe heart failure, should not use this medication, and if symptoms of heart failure occur, they should consult a doctor immediately. Patients with active bladder cancer or a history of bladder cancer should carefully consider the risks and benefits before administering this medication. It should not be given to pregnant or breastfeeding women, and safety has not been established in pediatric patients. Elderly patients may have decreased kidney function, so dosage adjustment and kidney function testing are necessary. This medication may interact with other drugs; therefore, it is essential to inform the doctor or pharmacist of any other medications being taken. While taking this medication, regular blood sugar tests and evaluations of liver and kidney functions should be conducted to monitor health conditions periodically. In case of overdose, it is essential to visit a medical institution immediately for appropriate treatment, as metformin can be removed from the blood by dialysis. Alcohol can increase the risk of side effects from this medication, so excessive drinking should be avoided while taking this medication. During the course of taking this medication, consistent adherence to dietary and exercise therapy is necessary, and if symptoms of hypoglycemia or lactic acidosis occur, immediate consultation with medical personnel is required.

Serious side effects

Severe lactic acidosis, hypoglycemia, congestive heart failure, severe edema, excessive edema associated with weight gain, liver failure, jaundice, acute kidney function deterioration, severe skin reactions, severe allergic reactions, severe headaches, seizures, confusional state, paralysis, hematuria, urinary disturbances, urgency, significant neurological symptoms

Mild side effects

• Diarrhea
• headache
• nausea
• upper respirator tract infection
• urinary tract infection
• sinusitis
• dizziness
• lower limb edema
• weight gain
• muscle pain

Store this medication in a tightly closed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

White to grayish-white rectangular film-coated tablet

Package unit

30 tablets/PTP[(10 tablets/PTP*3)]