Nytedro Capsule 500mg (Cefadroxil Hydrate)

Adult dose

1) For urinary tract infections: For uncomplicated lower urinary tract infections (e.g., cystitis), administer cefadroxil 1 to 2g (activity) divided into 1 to 2 oral doses daily. For other urinary tract infections, administer 2g (activity) divided into two doses daily. 2) For skin and soft tissue infections: Administer 1g (activity) divided into 1 to 2 oral doses daily. 3) For pharyngitis and tonsillitis: For beta-hemolytic streptococcal infections of pharyngitis and tonsillitis, administer 1g (activity) divided into 1 to 2 oral doses for 10 days. ○ For children 1) For urinary tract infections and skin and soft tissue infections: Administer 30mg (activity) per kg of body weight divided into two oral doses daily. 2) For pharyngitis and tonsillitis: Administer 30mg (activity) per kg of body weight divided into 1 to 2 oral doses daily. For beta-hemolytic streptococcal infections, administer for at least 10 days. The solution should be administered as a suspension (for syrup form. Teaspoon: about 5mL). Body weight (Kg) 125mg/5mL 250mg/5mL 500mg/5mL 4.5 1 teaspoon - 9.1 2 teaspoons 1 teaspoon 13.6 3 teaspoons 1½ teaspoons 18.2 4 teaspoons 2 teaspoons 1 teaspoon 22.7 5 teaspoons 2½ teaspoons 1¼ teaspoons 27.3 6 teaspoons 3 teaspoons 1½ teaspoons 31.8 and above - - 2 teaspoons ○ For renal impairment patients For patients with renal impairment, the dosage of cefadroxil should be adjusted based on creatinine clearance to avoid drug accumulation. The following dosage regimen is recommended. Specifically, an initial dose of 1000mg (activity) for adults should be adjusted based on creatinine clearance (mL/min/1.73m2) to 500mg (activity) at the following intervals. Patients with a creatinine clearance of more than 50mL/min can be treated similarly to those with normal kidney function. Creatinine clearance Dosage interval 0 to 10mL/min 36 hours 10 to 25mL/min 24 hours 25 to 50mL/min 12 hours Adjust according to age and symptoms.

Child dose

1) For urinary tract infections, skin, and soft tissue infections: Administer 30mg (activity) per kg of body weight divided into two oral doses daily. 2) For pharyngitis and tonsillitis: Administer 30mg (activity) per kg of body weight divided into 1 to 2 oral doses daily.

This drug should not be used in patients who have previously experienced shock due to this medication. Patients with a history of allergic reactions to cephalosporin antibiotics should also not take this drug. It should not be administered to patients suffering from specific infections like infectious mononucleosis. This drug contains lactose and should not be used in patients with a genetic disorder that impairs lactose digestion. When using this drug, careful consideration must be given for patients with a known history of allergic reactions, and it should only be administered cautiously when absolutely necessary. Caution is also advised for patients allergic to penicillin antibiotics. Patients with a family history of bronchial asthma or allergic symptoms such as skin rashes or hives should be careful. Special attention should be given to patients with severely impaired kidney function when administering this drug. Patients who are not able to eat well or are receiving parenteral nutrition, aged individuals, or those in poor general condition may show signs of vitamin K deficiency and should be closely monitored. Administration should also be done cautiously in patients with a history of gastrointestinal diseases, particularly colitis. Patients allergic to Yellow No. 5 dye should take precautions. This drug can rarely cause shock, so upon the appearance of any unusual symptoms, it must be discontinued immediately, and appropriate treatment should be sought. Hypersensitivity reactions may occur, such as skin rashes, hives, facial swelling, itching, fever, and anaphylaxis, and should be immediately halted if they occur. Abnormal reactions such as decreased blood cell counts or elevated liver function levels have been reported, so regular testing is necessary. Severe kidney impairment can occur, so if there are signs of kidney dysfunction, the use of this medication must be stopped immediately. Gastrointestinal reactions may include diarrhea, nausea, abdominal pain, gastritis, and if severe colitis symptoms appear, it must be stopped immediately. Respiratory adverse reactions like interstitial pneumonia or eosinophilic pulmonary infiltrates may occur, so symptoms of difficulty breathing should be monitored. Oral inflammation or candidiasis may also occur, though rarely. Symptoms of the central nervous system such as dizziness, drowsiness, and headache may present, and seizures have been reported rarely. Serious skin reactions like Stevens-Johnson syndrome can occur, so the skin condition should be closely monitored. Symptoms of hemorrhagic tendency due to vitamin K deficiency or vitamin B complex deficiency may present. Other symptoms may include genital itching, candidiasis, joint pain, etc. When using this medication, it is advisable to conduct sensitivity tests to prevent the occurrence of resistant strains and to take it for only the required minimum duration. It is crucial to thoroughly check the patient’s history to prevent allergic reactions. If hypersensitivity occurs, the administration of the drug must be stopped immediately, and appropriate treatment such as oxygen supply, intravenous fluids, epinephrine, antihistamines, and corticosteroids should be provided. Long-term use requires regular blood, kidney, and liver function tests. Adjustments in dosage are necessary for patients with reduced kidney function, and the drug should be stopped immediately if seizures occur. Care should be observed when using this drug with other renal-affecting medications, as it can exacerbate kidney damage. Co-administration with specific drugs may increase the concentration of this medication, so physician's direction must be followed. During pregnancy, its safety has not been established; therefore, it should only be used with caution when necessary. Caution is also advised in nursing mothers. Elderly patients may experience adverse reactions more readily due to weakened bodily functions, necessitating adjustments in dose and administration intervals, with careful observation of their condition. The risk of bleeding from vitamin K deficiency is also increased, so caution is warranted. This medication may influence the results of some clinical tests, which should be taken into consideration during testing. Finally, this medication may cause increased sensitivity to sunlight; therefore, protective measures should be taken when going outdoors.

Serious side effects

• Hives
• shock
• anaphylaxis
• severe colitis with blood in stool
• difficulty breathing
• interstitial pneumonia
• eosinophilic pulmonary infiltration
• Stevens-Johnson syndrome
• seizures
• bleeding tendency

Mild side effects

• Rash
• erythema
• facial swelling
• angioedema
• mucosal blistering
• itching
• fever
• thrombocytopenia
• granulocytopenia
• agranulocytosis

This medication should be stored in a tightly sealed container to prevent air or moisture ingress and at a temperature between 1°C and 30°C, which is safe for maintaining its efficacy over a prolonged period.

Appearance

A hard capsule with a reddish-brown upper part and a white lower part containing a white to pale yellow powder.

Package unit

10 capsules/bottle, 30 capsules/bottle, 100 capsules/bottle, 300 capsules/bottle, 500 capsules/bottle,