Syscare 10 mg (Solifenacin Succinate)

Adult dose

For adults (including elderly patients), the recommended dose is 5mg once daily. If needed, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dose adjustment is required for the following patients. 1. Patients with renal impairment: No dose adjustment is necessary for patients with mild or moderate renal impairment (creatinine clearance>30ml/min). For patients with severe renal impairment (creatinine clearance≤30ml/min), administer with caution and do not exceed 5mg once daily. 2. Patients with hepatic impairment: No dose adjustment is necessary for patients with mild hepatic impairment. For patients with moderate hepatic impairment (Child-Pugh class B), administer with caution and do not exceed 5mg once daily. 3. Patients receiving strong cytochrome P450 3A4 (CYP3A4) inhibitors: For patients receiving ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used in certain patients. For example, patients with urinary retention who have difficulty urinating or severe gastrointestinal diseases should not take this medication. Additionally, patients with severe myasthenia gravis, glaucoma, or allergies to this medication or its ingredients may also be at risk if they take it. Patients undergoing hemodialysis or with severely impaired liver and kidney function should avoid this medication. Caution is required when administering this medication to some patients. Dose adjustment may be needed for patients at risk of bladder outlet obstruction or with gastrointestinal obstruction, and those with moderate to severe impairment of kidney or liver function. Furthermore, caution is necessary when taken with certain medications, and patients with autonomic nervous system issues should be careful. Side effects such as dry mouth, constipation, blurred vision, urinary retention, and dry eyes may occur while taking this medication. In particular, dry mouth and constipation are reported frequently, and the incidence of these side effects increases with higher doses. Serious gastrointestinal issues, angioedema, or allergic reactions can occur infrequently, so consult a doctor immediately if unusual symptoms appear. This medication may cause drowsiness or blurred vision when driving or operating machinery, so caution is necessary. Patients with cardiac issues such as QT prolongation syndrome or hyperkalemia should be especially careful due to the risk of cardiac arrhythmias. Taking this medication with other anticholinergic drugs may enhance its effects or exacerbate side effects, and can decrease the effectiveness of medications that promote gastrointestinal motility. As this medication is metabolized in the liver, dose adjustments may be needed when taken with drugs that inhibit certain hepatic metabolic enzymes. Safety during pregnancy has not been established, so it should be used cautiously if pregnant, and nursing mothers are advised to avoid use as it may be excreted in breast milk and affect the baby. Its safety and efficacy in children have not been proven, so it should not be used in pediatric patients. In the case of overdose, immediate medical attention is required; induce vomiting should be avoided, and appropriate measures such as administration of activated charcoal should be taken. Overdose may result in central nervous system symptoms, heart problems, and urinary elimination issues, necessitating prompt action.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• angioedema
• nausea

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature to ensure the safety of the medication's efficacy.

Appearance

Light pink round film-coated tablet

Package unit

10 tablets/box [100 tablets (10 tablets/PTPX10)]