Megaclarithin Tablets 250 mg (Clarithromycin)

Adult dosage

Adults: The usual dosage is 250mg (potency) of clarithromycin per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) per dose twice daily. Do not administer this drug to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500mg (potency) of this drug 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin at 500mg (potency) per dose 3 times daily for 14 days (1～14 days), and administer omeprazole 40mg once daily for 28 days (1～28 days).

Children's dosage

Children aged 12 years and older: same as adults Children under 12 years: use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, patients with allergies to any of its components or those who have experienced allergic reactions to similar antibiotics should avoid taking it. Additionally, patients with severe cardiac arrhythmias or severely impaired liver or kidney function should not use it. Pregnant or breastfeeding women should also avoid this medication. Serious side effects may occur when this medication is taken with certain other drugs, so anyone currently taking medication should consult their doctor or pharmacist. This medication is primarily excreted through the liver and kidneys, so caution is needed for patients with impaired liver or kidney function. Elderly patients or those with heart diseases should be carefully monitored when using this medication. During use, adverse effects such as allergic reactions, gastrointestinal disturbances, skin rashes, breathing difficulties, and cardiac abnormalities may occur; if these symptoms develop, doctors should be notified immediately. Similar to other antibiotics, this medication can affect the balance of intestinal flora, potentially leading to diarrhea or pseudomembranous colitis, so any persistent diarrhea should be discussed with a healthcare provider. Long-term or excessive use may lead to hearing impairment or tinnitus, so it is important to adhere to the prescribed dosage and administration. Moreover, this medication can interact with various other drugs; if taking other medications, it is essential to consult with a specialist. It is advised not to use this medication during pregnancy or breastfeeding, and caution should be exercised in children under 12 years of age. In the case of overdose, gastrointestinal disturbances or central nervous system abnormalities may appear, and immediate medical attention should be sought.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal ulceration, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavior changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrosis syndrome, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, anorexia, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, venous thrombophlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, cardiac arrest, atrial fibrillation, QT prolongation on ECG, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, abdominal bloating, tongue discoloration, tooth discoloration, bullous dermatosis, papular rash, acne, Henoch-Schonlein purpura

This medication is sensitive to light; it should be stored in a container that blocks light. Additionally, it is important to keep it at room temperature between 15 and 30 degrees Celsius to maintain its effectiveness.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle