Megaclober Tablets (Acyclovir)

Adult administration

For the treatment of herpes simplex virus infections, administer acyclovir 200 mg 5 times a day at 4-hour intervals for 5 days, and treatment may be extended in cases of severe primary infections. For the prevention of herpes simplex infections in immunocompetent patients, administer 200 mg 4 times daily at intervals of about 6 hours, or 400 mg twice daily at 12-hour intervals. For patients with impaired immune function, for the prevention of herpes simplex infections, use 1

Child administration

For children over 2 years: dose as per adult dosage For children under 2 years: administer half of the adult dose For chickenpox treatment in children over 2 years: administer 20 mg per kg of body weight 4 times a day for 5 days (maximum per dose

This medication should not be used in patients who have had allergic reactions to this drug, its components, or valaciclovir. Patients with impaired renal function may experience neuropsychiatric adverse effects more easily when using this medication, so caution is advised. Patients with compromised liver function should be administered this medication carefully, as there is a risk of further deterioration in liver function. Infants and children should use this medication with extra caution, and it is advisable to use the minimum necessary dose. Elderly patients may have decreased renal function, which can increase blood levels of this medication and result in more frequent adverse reactions; therefore, the dosage and administration intervals should be adjusted accordingly. During treatment with this medication, serious allergic reactions, such as anaphylactic shock, can rarely occur. If symptoms such as low blood pressure, difficulty breathing, or tightness in the chest appear, administration should be stopped immediately and medical assistance sought. Skin reactions, such as rashes, fever, blisters, and urticaria, can occur. If these symptoms arise, administration should be discontinued and appropriate treatment initiated. Alopecia, severe dermatitis, and syndromes that cause significant damage to the skin and mucosal membranes may develop, so skin status should be monitored closely. Various neuropsychiatric symptoms, including confusion, hallucinations, seizures, drowsiness, anxiety, and movement disorders, may occur, particularly in the elderly and patients with renal impairment, so monitoring for these symptoms is important. This medication may affect renal function, leading to renal failure or symptomatic urinary abnormalities; therefore, it is essential to regularly check urine status and renal function. Blood-related symptoms such as leukopenia, bleeding, and anemia may develop, necessitating blood tests to monitor the condition. Liver function abnormalities may result in hepatitis, jaundice, or elevated liver enzyme levels, so liver health should be monitored carefully. Gastrointestinal symptoms such as gastritis, nausea, vomiting, and abdominal pain may occur; if symptoms are severe, treatment should be stopped, and medical advice sought. Systemic symptoms such as fever, swelling, weakness, and headache can occur, so monitoring overall health is crucial. Muscle or joint pain may occur; if discomfort persists, it should be reported. Cardiac symptoms such as arrhythmias, chest pain, and fluctuations in blood pressure may appear, necessitating monitoring of heart status. Difficulty in urination or urinary obstruction can appear rarely; if there are difficulties in passing urine, medical advice should be sought. This medication is used for treating simple herpes, chickenpox, and herpes zoster. If symptoms do not improve or worsen, alternative treatments should be considered. Treatment is most effective when started early during the onset of symptoms; for herpes zoster, treatment should begin within 5 days of the onset of skin symptoms, and for chickenpox, within 3 days. Patients with immunocompromised functions should consider intravenous administration forms for treatment. During administration of this medication, especially at high doses, ensuring adequate fluid intake is essential to reduce the risk of dehydration and nephrotoxicity. In the case of recurrent genital herpes treatment, the necessity to continue after one year of administration should be reviewed. This medication may cause drowsiness or consciousness disturbances, so caution is advised when driving or operating dangerous machinery, especially for patients with renal impairment. Interactions with other medications can occur; particularly when used concurrently with drugs affecting renal function or certain other medications, consultation with a healthcare professional is recommended. Pregnant women or those likely to become pregnant should carefully consider the risks and benefits of using this medication, and during breastfeeding, discontinuation is necessary as this drug's components are transferred in breast milk. The safety of this medication in children or infants has not been fully established, so it should only be used cautiously when absolutely necessary. Elderly patients should use this medication cautiously, adjusting the dose and administration intervals due to possible prolonged drug retention in the body, with a need for adequate fluid intake. In the event of overdose, severe symptoms such as agitation, stupor, seizures, and somnolence may occur; immediate hospitalization and appropriate treatment are necessary, including possible blood dialysis.

Serious side effects

Urticaria, severe swelling, tightness in the chest, difficulty breathing, cold sweat, paleness, anaphylactic shock, anaphylactoid reactions, severe allergic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), jaundice, sudden and severe headache, seizures, disorientation, visual disturbances, paralysis, renal failure, significant swelling accompanied by increased blood pressure, convulsions

Mild side effects

• Photosensitivity reactions
• fixed drug eruptions
• rashes
• fever
• blisters
• alopecia
• erythema multiforme
• altered consciousness
• disturbed sense of direction
• concentration disorders

This medication should be kept in a tightly closed container to prevent exposure to air or moisture, and it is best kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage maintains the drug's effectiveness and ensures safety in use.

Appearance

Light blue round tablets

Package unit

30 tablets/bottle, 200 tablets/bottle