Glufa XR Sustained Release Tablet 1000mg (Metformin Hydrochloride)

Adult dose

The usual initial dose is 500mg of Metformin Hydrochloride sustained-release tablet once a day with the evening meal. After one week, blood glucose levels should be measured to adjust the dose, and it can be administered with the evening meal up to a maximum of 2000mg per day. Dosage increases should be made weekly by 500mg, up to a maximum of 2000mg once a day. If blood glucose control is not achieved with 2000mg once a day, consider 1000mg twice a day.

This medication can rarely cause a very serious condition called lactic acidosis. Lactic acidosis occurs when there is an excessive buildup of lactic acid in the body and, if severe, can be life-threatening. Additionally, caution is needed when used with insulin or other diabetes medications due to the risk of hypoglycemia. Patients with moderate or severe renal impairment, dehydration, severe infections, or rapidly worsening cardiac function should not use this medication. Patients with acute heart failure or serious heart disease, and those who are scheduled for examinations using radiocontrast agents containing iodine, should discontinue or not use this medication. This medication should not be given to patients with allergy to its ingredients or to patients with type 1 diabetes, and those with metabolic acidosis. Patients with severe infections or trauma, who are in very poor condition, should temporarily discontinue this medication and resume after recovery. If surgery is planned, especially if eating or fluid intake is limited, this medication should be discontinued 48 hours before the surgery and should only be resumed after confirming normal kidney function post-surgery. Caution is also needed for patients with very poor nutritional status or problems with liver or adrenal function. During the course of this medication, kidney function should be regularly monitored, and it should be discontinued if kidney function deteriorates. Also, caution should be taken during irregular meals or vigorous exercise as there is a risk of hypoglycemia and lactic acidosis. Gastrointestinal symptoms (nausea, vomiting, diarrhea, etc.) may occur frequently at the beginning of treatment but often improve naturally over time. This medication can cause vitamin B12 deficiency, so it is advisable to regularly check vitamin B12 levels. During pregnancy, it may affect the fetus, so if pregnancy is planned or if the patient is pregnant, the use of this medication should be discussed with a physician. During breastfeeding, since this medication is secreted in breast milk, it should be carefully decided whether to continue breastfeeding. Elderly patients often experience decreased kidney function, so drug dosage should be adjusted, and kidney function should be monitored frequently. In case of overdose, this medication can be removed by hemodialysis. If overdose is suspected, seek medical attention immediately. This medication may interact with other drugs, so if other medications are being taken, be sure to inform a physician or pharmacist. Alcohol may increase the risk of side effects from this medication, so it's best to avoid drinking while taking it. While taking this medication, regular checks of blood glucose, kidney function, and blood tests should be performed to monitor treatment effectiveness and side effects.

Serious side effects

Lactic acidosis, hives, severe swelling (edema), difficulty breathing, sudden and very severe headache, severe edema or urinary abnormalities accompanied by increased blood pressure

Mild side effects

• Vitamin B12 deficiency
• taste disorder
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication should be stored in a tightly closed container to protect it from air and moisture, and kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness over time.

Appearance

White rectangular sustained-release film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle