Megacarve Tablet 25 mg (Carvedilol)

Adult dose

Do not increase the dose or discontinue treatment without the physician's instructions. 1. Essential hypertension 1) Adults (1) For the first 2 days, administer 12.5 mg of carvedilol orally once daily, then administer 25 mg orally once daily. (2) The usual dose is 25 mg orally once daily for 2 weeks. If a dose increase is needed, increase to 25 mg per dose twice daily. The maximum dose per administration is 25 mg, and the maximum daily dose is 50 mg. 2) Elderly patients In some elderly patients, 12.5 mg once daily may provide an adequate effect. However, the dose may be increased if the effect is insufficient after 2 weeks of treatment. 2. Chronic stable angina 1) For the first 2 days, administer 12.5 mg of this medicine per dose twice daily orally, then administer 25 mg per dose twice daily orally. 2) The usual dose is 25 mg per dose twice daily for 2 weeks. If an increase is needed (excluding elderly patients), the dose may be increased to 50 mg per dose twice daily. 3. Congestive heart failure Before starting treatment with this medicine, the patient's existing standard treatment regimen (conventional treatment for chronic heart failure with an ACE inhibitor, a diuretic, and usually a digitalis preparation) must be stable. Fluid retention should also be minimized before starting treatment with this medicine. 1) In general, the initial dose is 3.125 mg of this medicine per dose twice daily orally for 2 weeks. If the patient tolerates this treatment well, increase the dose to 6.25 mg per dose twice daily for 2 weeks, then to 12.5 mg per dose twice daily for 2 weeks, and then to 25 mg per dose twice daily. 2) After taking each dose level for at least 2 weeks, gradually increase the dose to the highest dose the patient can tolerate. 3) The minimum effective dose is 6.25 mg per dose twice daily. The maximum dose is 25 mg per dose twice daily for patients weighing 85 kg or less, and 50 mg per dose twice daily for patients weighing more than 85 kg. 4) To control the rate of absorption, it is recommended that the medicine be taken with meals in the morning and evening. Taking it with meals slows the rate of absorption and may reduce the incidence of orthostatic hypotension.

This medication should not be used in certain patients. For example, patients who are allergic to this drug or its components or those in cardiogenic shock may be at risk if administered. Patients with very slow heartbeats or problems with heart conduction, those with cor pulmonale, patients with severe metabolic disorders due to diabetes, and those with significantly weakened heart function should avoid its use. Additionally, patients with respiratory diseases or a history of asthma, those with secondary hypertension, acute pulmonary embolism, those taking certain blood pressure medications, patients with severe hypotension, those with very poor liver function, pregnant or breastfeeding women should also be careful. Furthermore, patients with a genetic lactose metabolism disorder should not take this medication due to the lactose contained in it. Diabetic patients or those sensitive to allergic reactions, as well as those with a history of cutaneous conditions related to beta-blockers should use this medication cautiously. Patients with hypotension or decreased kidney function, unstable cardiac conditions, heart failure patients, the elderly, and patients with specific heart diseases should also take care. While taking this medication, symptoms such as dizziness, headaches, and fatigue may occur, and in severe cases, heart rate may slow down significantly or blood pressure may drop sharply, necessitating regular checks of cardiac function and blood pressure. If symptoms of liver dysfunction appear, immediate consultation with a medical professional is required. It is advisable to avoid driving or operating dangerous machinery while on this medication. This drug may interact with other medications, so especially when taking antihypertensives, insulin, antidepressants, antiarrhythmics, anesthetics, and alcohol, it is essential to consult a doctor. Women who are pregnant or breastfeeding should not take this medication, and its safety has not been established in children and adolescents under 18 years of age. The elderly may experience increased drug concentrations due to decreased liver function, so it is advised to start with a lower dose and administer cautiously. In case of overdose, symptoms such as severe hypotension, decreased heart rate, difficulty breathing, and altered consciousness may appear, and immediate contact with a medical institution for appropriate treatment is required. This medication may discolor when exposed to light, so it should be stored in an opaque container and kept out of the reach of children. Furthermore, sudden discontinuation of this medication may worsen symptoms, so the dose should be gradually reduced according to the doctor's instructions.

• Dizziness
• headache
• fatigue
• weakness
• hallucinations
• confusion
• depression
• sleep disorders
• nightmares
• psychosis

This medicine may be sensitive to light, so it should be stored in a light-blocking, airtight container. Additionally, to maintain the effectiveness of the drug, it should be stored at room temperature between 1 degree and 30 degrees Celsius.

Appearance

White round tablet

Package unit

90 tablets (10 tablets/PTP × 9)