Amoclara 625 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children aged 12 years or older or weighing 40 kg or more should take 250 mg/125 mg of amoxicillin/clavulanate potassium orally three times a day every 8 hours. In cases of severe or respiratory infections, dosage can be increased to 500 mg/125 mg. In cases of renal impairment, the dosage should be adjusted based on creatinine clearance. - For creatinine clearance above 30 mL/min: no dosage adjustment is necessary.

Child dose

Administered in the same manner as adults and children aged 12 years or older or weighing 40 kg or more. In cases of renal impairment, dosage should be appropriately reduced based on creatinine clearance.

This drug is a beta-lactam antibiotic and should not be used in patients with a history of hypersensitivity to penicillin or cephalosporin antibiotics. Patients with infectious mononucleosis or lymphocytic leukemia are at higher risk of rash and should avoid this medication. Patients with a history of liver dysfunction or jaundice should also be cautious as there is a risk of recurrence upon using this medication. Patients with impaired liver function or moderate to severe renal impairment may have elevated drug concentrations and should adjust the dosing intervals or use the drug carefully. Patients with allergic tendencies or symptoms like bronchial asthma, rashes, or hives should be cautious as hypersensitivity reactions may occur with this medication. If there are gastrointestinal disorders such as vomiting or diarrhea, drug absorption may decrease, so the dosing status should be carefully monitored. This medication may cause gastrointestinal side effects such as diarrhea, nausea, vomiting, and in severe cases, pseudomembranous colitis or acute pancreatitis may occur, so if symptoms appear, seek immediate medical attention. Symptoms of liver dysfunction have also been reported, especially in the elderly and males, so liver function tests are necessary during long-term use. Serious skin reactions like rashes, Stevens-Johnson syndrome, or anaphylactic shock may occur infrequently, so if any abnormal symptoms occur, discontinue use immediately and seek medical help. Blood-related abnormalities such as leukopenia, anemia, and thrombocytopenia have been rarely reported, so be vigilant for symptoms of bleeding or infection. Central nervous system abnormalities may be rare and could include anxiety, agitation, confusion, headache, and seizures, so notify healthcare providers if neurological symptoms appear. This medication is excreted through the kidneys, so it should be administered carefully in patients with decreased kidney function, and regular kidney function tests are necessary. During treatment with this drug, there is a risk of bleeding due to vitamin K deficiency, so be aware of bleeding symptoms. Pregnant women or those who may become pregnant should avoid use unless under specific circumstances, and nursing mothers should be cautious as diarrhea or hypersensitivity may occur in infants. Children, especially those under 12 years old or weighing less than 40 kg, have limited experience with this drug and it is not recommended. In elderly patients, there is an increased risk of side effects due to decreased physiological functions, so doses and intervals should be adjusted carefully and monitored. This medication may interact with other drugs, so consult healthcare providers when using it with anticoagulants, probenecid, allopurinol, disulfiram, etc. In cases of overdose, gastrointestinal symptoms, renal failure, and seizures may occur, so seek medical intervention immediately, and if necessary, the drug can be removed through dialysis. This medication should be stored in a dry place at temperatures below 25 degrees Celsius, and always consult healthcare providers to comply with the appropriate dosage and administration before use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions. Severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, severe skin adverse reactions. Yellowing of the skin or eyes (jaundice), feeling extremely fatigued, liver abnormality (jaundice). Sudden and extremely severe headaches, thunderclap headaches, seizures, confusion, visual disturbances, paralysis, serious neurological symptoms.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be kept in a tightly closed container to prevent moisture, and stored in a cool and dry place, i.e., at a temperature below 25 degrees Celsius. Doing so will help maintain the drug's effectiveness for a longer period.

Appearance

White or nearly white oval film-coated tablets

Package unit

40 tablets/box [4 tablets/PTP X 10]