Question 1

What are the indications and effects of Clarithromycin 250 mg Tablets?

Accepted Answer

This medicine is effective against various bacteria and is used to treat lower respiratory tract infections such as bronchitis and pneumonia, as well as upper respiratory tract infections including pharyngitis and sinusitis. It is also effective for infections of the skin and skin tissues, and helps treat mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare. Additionally, it is used to eradicate Helicobacter pylori in patients with duodenal ulcers, contributing to the improvement of gastrointestinal issues. Thus, it is used to treat a wide range of bacterial infections.

Question 2

What are the dosage and administration instructions for Clarithromycin 250 mg Tablets?

Accepted Answer

Adults: The usual dose is 250mg (potency) of clarithromycin per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be halved: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer for more than 14 days to these patients.
Mycobacterial infections: Administer 500mg (potency) of this drug per dose twice daily. In this case, it should be administered in combination with other antimycobacterial drugs such as ethambutol, clofazimine, and rifampin.
Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500mg (potency) of this drug 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Answer

Children aged 12 years and older: Same as adults
Children under 12 years: Use clarithromycin dry syrup.

Question 3

What are the side effects of Clarithromycin 250 mg Tablets?

Accepted Answer

Shock, anaphylactic symptoms, difficulty breathing, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, arthralgia, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral erosions, upper abdominal pain, dry mouth, tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremors, paresthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, ageusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, auditory dysfunction, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, acute generalized pustular eruption, soft tissue infection, candidiasis, gastroenteritis, infection, vaginitis, angioedema, decreased appetite, insomnia, nervousness, auditive distortion, psychotic disorders, confusion, abnormal dreams, mania, headache, loss of consciousness, movement disorders, vestibular dizziness, drowsiness, tremors, convulsions, dysosmia, vestibular vertigo, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, extrasystole, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyltransferase, liver failure, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle cramping, musculoskeletal rigidity, myopathy, elevated blood urea, venous inflammation at injection site, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin/globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

Question 4

What precautions should be taken when using Clarithromycin 250 mg Tablets?

Accepted Answer

This medicine should not be administered to patients who are allergic to certain ingredients or who have had hypersensitivity reactions to macrolide antibiotics.

Patients taking certain medications that may cause abnormal heartbeats should use this medicine with caution as it may pose risks.

Patients with severe liver or kidney dysfunction, pregnant or breastfeeding women, and those with central nervous system infections should avoid using this medicine.

As this medicine is excreted through the liver and kidneys, patients with liver or kidney impairment should use it with caution, and elderly patients or those with heart diseases should also be cautious.

During the use of this medicine, signs such as allergic reactions, skin rashes, difficulty breathing, severe diarrhea, abnormal liver function, kidney function decline, and central nervous system symptoms may occur, so seek immediate medical attention if any of these symptoms appear.

This medicine is likely to interact with other drugs, especially those affecting the heart, those metabolized in the liver, blood sugar-lowering agents, certain anticoagulants, and specific antiviral agents; therefore, consultation with a physician or pharmacist is mandatory before use.

Pregnant or breastfeeding women should not use this medicine; if it is unavoidable, breastfeeding should be stopped.

The safety of this medicine in children, especially those under 12 years of age, has not been sufficiently verified, so caution is necessary.

In case of overdose, gastrointestinal disturbances or central nervous system symptoms may occur, requiring immediate visit to a medical institution, and this medicine cannot be removed through hemodialysis, so caution is warranted.

When stored, this medicine should not be refrigerated, and it should be protected from direct sunlight and stored at room temperature.

Clarithromycin 250 mg Tablets

Summary

Ingredients

Efficacy & effects

Dosage and Administration

Adult dosage

Children's dosage

Precautions

Side effects

Storage

Appearance and packaging

Appearance

Package unit

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