Zerobik Capsule 120 mg (Orlistat)

Adult dose

The recommended dose is 120 mg of orlistat orally 3 times daily, taken with a meal containing fat or within 1 hour after a meal. Patients should continue a nutritionally balanced, mildly hypocaloric diet in which approximately 30 % of calories are derived from fat. Daily intake of fat, carbohydrates, and protein should be distributed evenly among the three meals. This medicine may be omitted if a meal is skipped or contains no fat. Because this medicine may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before this medicine or at least 2 hours after it, such as at bedtime. Taking more than 120 mg of this medicine 3 times daily does not increase its effectiveness. Based on measurements of fecal fat, the effect of this medicine appears 24 ∼ 48 hours after administration. After treatment is discontinued, fecal fat content generally returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this medicine for periods exceeding 4 years have not been evaluated. Studies have not been conducted in patients with hepatic and/or renal impairment or in elderly patients.

Child dose

Studies have not been conducted in children under 12 years of age.

This medication should not be used in patients with chronic malabsorption syndrome or complete biliary obstruction. Individuals with allergies to this medication or its ingredients should also avoid taking it. Pregnant or breastfeeding women should not take this medication. Liver damage has been rarely reported, so if any symptoms of liver dysfunction appear, it is important to immediately inform a doctor and discontinue use. Liver enzyme levels should be monitored through liver function tests. Additionally, patients with hyperoxaluria or calcium oxalate kidney stones should use it with caution. When taking this medication, gastrointestinal-related side effects may often appear, with symptoms including oily stools, abdominal distension, and constipation. These side effects are usually mild and transient, mostly appearing within 3 months and improving within 1-4 weeks. However, in some patients, they may persist for more than 6 months. There may be instances where medication is discontinued due to adverse reactions during treatment, particularly gastrointestinal symptoms, which are the most common reasons. Rarely, severe side effects such as hepatitis, allergic reactions, pancreatitis, and seizures have also been reported. This medication may reduce the absorption of fat-soluble vitamins (vitamins A, D, E, K) and beta-carotene, hence taking vitamin supplements is recommended. Vitamin supplements should be taken at least 2 hours before or after taking this medication for efficacy. The risk of gastrointestinal side effects may increase when taken with high-fat meals; thus, it is advisable to distribute fat intake evenly across three meals a day. Furthermore, excessive weight loss can increase the risk of gallstones, so caution is warranted. If symptoms of liver dysfunction (loss of appetite, itching, jaundice, dark urine, pale stools, upper abdominal pain) occur, immediate consultation with a doctor is necessary. This medication may interact with certain drugs, so inform your doctor or pharmacist if you are taking other medications. Extra caution is needed when taken alongside anticoagulants, cyclosporine, anticonvulsants, and antiretroviral medications. This medication is not recommended during pregnancy or breastfeeding. Its safety and efficacy have not been established in children under 12 years of age, therefore it should not be used. In cases of overdose, no specific adverse reactions have been reported, but monitoring for 24 hours is required.

• Fatty stools
• abdominal bloating and flatulence
• frequency of stool
• fatty/stools with fat
• oily stools
• increased bowel movements
• bowel incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea

This medication should be stored in a tightly sealed container to protect it from air, light, and moisture, with a recommended temperature below 25 degrees Celsius. Proper storage will maintain the effectiveness of the medication over time and prevent degradation.

Appearance

Hard capsules with a white or whitish powder or granules and greenish-blue upper and lower surfaces.

Package unit

30 capsules/bottle, 300 capsules/bottle