Zerobecapsule 60mg (Orlistat)

Adult dose

The recommended dose is 120 mg of orlistat orally 3 times daily, taken with a meal containing fat or within 1 hour after a meal. Patients should continue a nutritionally balanced, mildly hypocaloric diet in which approximately 30 % of calories are derived from fat. Daily intake of fat, carbohydrates, and protein should be distributed evenly among the three meals. This medicine may be omitted if a meal is skipped or contains no fat. Because this medicine may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before this medicine or at least 2 hours after it, such as at bedtime. Taking more than 120 mg of this medicine 3 times daily does not increase its effectiveness. Based on measurements of fecal fat, the effect of this medicine appears 24 ∼ 48 hours after administration. After treatment is discontinued, fecal fat content generally returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this medicine for periods exceeding 4 years have not been evaluated. ○ Studies have not been conducted in patients with hepatic and/or renal impairment or in elderly patients.

Child dose

Studies have not been conducted in children under 12 years of age.

This medication should not be used in patients with chronic malabsorption syndrome or with conditions involving cessation of bile secretion. Patients allergic to this medication or its components, pregnant women or those who may become pregnant, and breastfeeding women should also refrain from taking it. Liver damage has been reported rarely, so if symptoms of liver dysfunction occur, promptly inform a doctor and discontinue use of this medication. It is important to check liver enzyme levels through liver function tests. Additionally, since urinary excretion of oxalates may increase, patients with hyperoxaluria or calcium oxalate kidney stones should use this medication with caution. Gastrointestinal adverse effects may occur frequently with this medication, including abdominal distension, flatulence, constipation, oily stools, increased bowel movements, or fecal incontinence. These symptoms usually appear within 3 months of starting treatment and most improve within 4 weeks, but in some patients, may persist for more than 6 months. There may be cases where treatment is discontinued due to adverse reactions while taking this medication, primarily due to gastrointestinal issues. Occasionally, serious liver damage such as hepatitis or liver failure may occur, so liver function should be monitored. The risk of gastrointestinal adverse effects increases when taken with a high-fat meal, so it is recommended to distribute fat intake evenly across three meals a day. Additionally, this medication may reduce the absorption of fat-soluble vitamins and beta-carotene, so it is advised to take vitamin supplements at least 2 hours before or after taking this medication. Pregnant or breastfeeding women should not take this medication, and its safety and efficacy in children under 12 have not been established. This medication may interact with other drugs, so it is important to follow a doctor's instructions when taking it alongside cyclosporine, anticoagulants, anticonvulsants, antiretrovirals, etc., and to periodically check blood coagulation status or drug concentration. In case of overdose, serious side effects are rare, but monitoring the patient's condition for 24 hours is necessary. For storage, keep it out of the reach of children, protect it from light and moisture, and maintain its original packaging.

• Fatty stool
• abdominal distension and flatulence
• increased frequency of bowel movements
• fatty/stool with fat
• increased bowel movements
• bowel incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea
• rectal pain/discomfort

This medication is sensitive to air, light, and moisture, so it should be stored in a sealed container. Furthermore, it is important to keep it in a cool place below 25 degrees Celsius to maintain its effectiveness.

Appearance

A hard capsule with a white or off-white powder or granules and a yellowish hard shell.

Package unit

30 capsules/bottle, 300 capsules/bottle