Ticaren 90mg (Ticagrelor)

Adult dose

Do not use this medicine in combination with other ADP receptor inhibitors (ticlopidine, clopidogrel, prasugrel). ㆍAcute coronary syndrome: Administer an initial dose of 180mg, followed by 90mg twice daily. Treatment is recommended for 12 months unless discontinuation of this medicine is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. ㆍPatients with a history of myocardial infarction (occurring at least 1 year previously) who are at high risk of thrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. - Patients who took 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. - Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuing a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). - The safety and efficacy of this medicine were evaluated at 3 years of follow-up. ㆍPatients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. - Refer to the dosage and administration for patients with acute coronary syndrome. - Data on the safety and efficacy of this medicine for use exceeding 3 years are limited. ㆍPatients with acute ischemic stroke or high-risk transient ischemic attack: Administer an initial dose of 180mg, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial loading dose of aspirin (300-325mg) is recommended in patients with acute ischemic stroke or high-risk transient ischemic attack. Method of administration This medicine is administered orally and may be taken with or without food. ㆍPatients who have difficulty swallowing the tablets should crush this medicine into a fine powder, disperse it in half a glass of water, and drink it immediately; rinse the glass with half a glass of water and drink again. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the nasogastric tube with water after administration. ㆍWhen switching from another antiplatelet agent to this medicine, start this medicine 24 hours after the last dose of the previous medication. ㆍIf a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. Patients with renal impairment No dose adjustment is necessary in patients with renal impairment. Patients with hepatic impairment No dose adjustment is necessary in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience in patients with moderate hepatic impairment is limited.

Child dose

The safety and efficacy have not been established in pediatric patients under 18 years of age (see the ‘Other’ section).

This medication is an agent that prevents platelets from aggregating and is used to reduce the risk of cardiovascular diseases such as myocardial infarction or stroke. It should not be used in patients with an existing bleeding condition or a history of intracranial hemorrhage. In cases of scheduled surgery, it is recommended to discontinue this medication at least 5 days before the procedure. If bleeding symptoms occur, medical personnel should be notified immediately, and if bleeding is suspected, treatment for the bleeding should be prioritized without stopping this medication. Patients with hypersensitivity to any components of this drug or severe liver dysfunction should not be treated with it, particularly when used in conjunction with certain strong medications. Caution should be exercised when administering this drug to patients at high risk of bleeding or those taking other medications that may induce bleeding. Special attention is necessary for patients at risk for bradycardia (slow heart rate) or those with asthma or chronic obstructive pulmonary disease when taking this medication. Symptoms such as shortness of breath may occur, and if these symptoms are severe or persistent, discontinuation of the medication should be considered. Caution is also needed for patients with a history of hyperuricemia or gout. Pregnant or breastfeeding women should avoid taking this medication, and women of childbearing age should take appropriate contraception to avoid pregnancy during treatment. The safety and efficacy of this medication in children under 18 have not been established, and it is not recommended. Overdosage may increase the risk of bleeding, and there is no specific antidote, so appropriate treatment according to symptoms is necessary. This medication may interact with other drugs, so if you are taking any other medications, it is essential to inform your healthcare professional. Dizziness or confusion may occur while driving or operating machinery, so caution is required. This medication should be stored in its original container and kept out of the reach of children.

Hemorrhage, intracranial hemorrhage, ocular hemorrhage, ear hemorrhage, hypotension, dyspnea, respiratory tract hemorrhage, gastrointestinal hemorrhage, diarrhea, nausea, indigestion, constipation, retroperitoneal hemorrhage, skin hemorrhage, rash, pruritus, muscle hemorrhage, urinary tract hemorrhage, reproductive tract hemorrhage, post-procedural hemorrhage, traumatic hemorrhage, thrombotic thrombocytopenic purpura, bradyarrhythmia, atrioventricular block, angioedema, confusion, dizziness, syncope, headache, vertigo, elevated serum creatinine, hyperuricemia, gout, chest pain, cough, pulmonary hemorrhage, pharyngitis, upper respiratory infection, asthma, pleural effusion, bronchitis, pneumothorax, pneumonia, pulmonary edema, asthenia, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal stenosis, dementia, migraine, paralysis, gait disturbance, rectal bleeding, anal bleeding, appendicitis, tendinopathy, bursitis, diabetes mellitus, hyperkalemia, hyperglycemia, hepatitis, snoring, aneurysm, heart failure, arrhythmia, palpitations, ventricular tachycardia, dysrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary tract infection, nephrolithiasis, cerebral ischemia, venous stenosis, cerebral infarction, arterial stenosis, angina pectoris, coronary thrombosis, myocardial ischemia, fungal infection, anemia, vestibular disorder, malignant neoplasm of male genital organs, chemical poisoning, post-procedural hematoma, laceration, road traffic accident, trauma, increased sputum, bronchiectasis, sleep apnea, pulmonary congestion, oral edema, influenza-like illness, tuberculosis infection, hyperthermia, unspecified hernia, choking, generalized edema, thrombosis, deep vein thrombosis, intracardiac thrombus, coagulation disorder, thrombocytosis, speech disorder, cerebral hypoxia, scalp tenderness, peripheral neuropathy, neck stiffness, voice disorder, seizure, neuropathy, neuralgia, dystonia, tremor, lower limb paralysis, coma, sensory impairment, oral pain, gastritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tendinitis, arthrosis, chondrocalcinosis, spinal osteoarthritis, arthritis, contact dermatitis, fungal dermatitis, erythematous rash, excessive keratinization, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, increased sweating, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, lipodystrophy, dehydration, hepatitis, cholelithiasis, gallbladder disease, increased alkaline phosphatase, fatty liver, drowsiness, neurosis, depression, memory impairment, erectile dysfunction, anxiety, orthostatic hypotension, exacerbation of hypertension, cyanosis, atrial dysrhythmia, atrial fibrillation, frequent urination, dysuria, urinary tract infection, conjunctival injection, eye pain, visual disturbances, sexual dysfunction, benign prostatic hyperplasia, ovarian cyst, amenorrhea, vaginitis, loss of taste, abnormal olfaction, increased TSH, hypothyroidism, injection site reaction, injection site pain, insomnia, anxiety, palpitations, bradycardia, atrial fibrillation, tinnitus, ear pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It should be kept at room temperature between 1 and 30 degrees Celsius.

Appearance

Yellow, round, biconvex film-coated tablets

Package unit

56 tablets/box [14 tablets/PTP×4]