Entife Bukjeong 40mg (Febuxostat)

Adult dosage

1. Adults This drug is administered at a dose of 40mg or 80mg once daily, regardless of meals. This drug acts very rapidly; recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is required in patients with mild to moderate renal impairment. The safety and efficacy of this drug have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30 mL/min). 3. Patients with hepatic impairment No special dosage adjustment is required in patients with mild to moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this drug have not been studied in patients with severe hepatic impairment (Child-Pugh class C).

This medication may increase the risk of cardiovascular mortality in patients with cardiovascular diseases, so patients with a history of cardiovascular diseases should consider other treatment options. Patients who have allergic reactions to this medication or have certain genetic metabolic disorders should not take it. Patients with liver diseases or thyroid dysfunction should undergo regular liver function tests and thyroid function tests before taking this medication and should consult with a physician if necessary. This medication is used to control uric acid levels, and it should not be initiated during an acute gout attack but started after the attack resolves. During the initial dosage, gout attacks may temporarily worsen, so it is recommended to use medications like non-steroidal anti-inflammatory drugs or colchicine to prevent this. While taking this medication, adverse effects such as liver function abnormalities, dizziness, and drowsiness may occur, so caution is required. If these symptoms are severe, immediate consultation with medical personnel is necessary. Furthermore, this medication may interact with other drugs, so if any other medications are being taken, it is essential to inform the physician or pharmacist. Pregnant or breastfeeding women are advised to avoid taking this medication, and there is no experience in administering it to children or adolescents under 18 years old, so it is not recommended. In case of overdose, there are no specific antidotes, so treatment should be provided according to the symptoms, and it should be stored out of reach of children.

Abnormal liver function, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, muscle pain, pruritus, shortness of breath, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina pectoris, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, melena, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, mood disorders, walking difficulties, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle contraction, muscle constriction, muscle weakness, musculoskeletal pain, muscle rigidity, change in taste, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory impairment, focal ischemia, drowsiness, mental disorders, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremor, restlessness, anxiety, depression, insomnia, excitability, decreased libido, neuroexcitability, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, shortness of breath, epistaxis, nasal dryness, increased nasal secretion, oropharyngeal edema, airway obstruction, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin rash, purpura, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin exfoliation, petechiae, photosensitivity, pruritus, purpura, skin discoloration, changes in pigmentation, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased leukocyte count, decreased leukocyte count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylaxis, shock, serious allergic reactions, hypersensitivity reactions, eosinophilia, systemic symptoms, fever, hematological disorders, renal disorders, liver disorders, liver failure, jaundice, liver impairment, abnormal liver function, angioedema, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to protect it from air and moisture, maintaining a storage temperature between 1 to 30 degrees Celsius. Maintaining proper temperature and container conditions can help preserve the efficacy and safety of the medication for a longer period.

Appearance

White to yellowish round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle