Pamdone Tablet 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, consider taking this medicine in the morning. Since donepezil reaches steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose increase, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, monitor for gastrointestinal adverse reactions. If this medicine is discontinued, its effects decrease gradually; no rebound effect occurs following abrupt discontinuation. Women aged 85 years or older with low body weight: Because adverse reactions occur frequently, careful monitoring is required. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

Pediatric patients: There is no experience with use in children.

This medication contains donepezil hydrochloride and is used to relieve symptoms of Alzheimer's-type dementia. However, individuals with hypersensitivity to this medication, women who are pregnant or nursing, and patients with certain genetic lactose intolerance disorders should not take this medication. Patients with heart disease, a history of peptic ulcers, asthma or obstructive pulmonary diseases, and extrapyramidal disorders such as Parkinson's disease should take special care when using this medication. This medication can cause heart rhythm problems, and serious side effects such as gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, muscle disorders, and respiratory distress may occur, so it is essential to consult medical personnel immediately if symptoms arise. Additionally, during the course of treatment, a variety of side effects such as dizziness, nausea, diarrhea, insomnia, hallucinations, depression, and others may occur, so caution is required. This medication is not approved for use in other types of dementia or memory disorders outside of Alzheimer's-type dementia, and its therapeutic effects should be evaluated regularly. If you have heart disease or are taking medications that may affect heart rhythm, you must inform medical personnel, as the risk of side effects may increase due to interactions with this medication. Women who are pregnant or nursing should avoid taking this medication, and if necessary, should do so under the guidance of a specialist. Safety in pediatric patients has not been established; therefore, it should not be used in children. This medication may affect driving or operating machinery; caution should be exercised based on symptoms after taking it. In case of overdose, dangerous symptoms such as vomiting, severe muscle weakness, and respiratory distress may occur; immediate emergency care should be sought, and atropine may be used as an antidote. This medication should be stored out of reach of children, and transferring it to another container may lead to decreased quality or accidents, so caution is required.

Syncope, bradycardia, heart block, prolonged QT interval, myocardial infarction, heart failure, peptic ulcer, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver function impairment, jaundice, cerebral seizure, epilepsy, convulsions, cerebral hemorrhage, cerebrovascular disorder, motor function disorder, ataxia, movement disorders, dystonia, tremors, involuntary movements, gait disturbance, abnormal posture, speech impairment, akinetic mutism, extreme muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, myoglobinuria, renal impairment, rhabdomyolysis, myalgia, lethargy, increased CK in blood and urine, dyspnea, acute pancreatitis, acute renal failure, sudden death, cold, loss of appetite, hallucinations, agitation, aggressive behavior, anxiety disorders, insomnia, drowsiness, increased libido, talkativeness, mania, nightmares, nervousness, nonsense, delusions, depression, confusion, apathy, hyperactivity, increased libido, hypersexuality, dizziness, tremors, stupor, thoracic stiffness, bradycardia, palpitations, sinoatrial block, atrioventricular block, hypertension, hypotension, atrial fibrillation, torsades de pointes ventricular tachycardia, ECG QT interval prolongation, diarrhea, nausea, vomiting, abdominal disorders, gastrointestinal bleeding, gastric and duodenal ulcers, constipation, salivation, fecal incontinence, hepatitis, rash, pruritus, muscle cramps, myalgia, incontinence, frequent urination, urinary retention, headache, fatigue, pain, toothache, facial flushing, malaise, lethargy, edema, fever, decreased body temperature, decreased hematocrit, leukopenia, anemia, thrombocytopenia, petechiae, abnormal dreams, decreased appetite, urinary tract infection, increased CPK, dehydration, hyperlipidemia, insomnia, hostility, irritability, drowsiness, depression, confusion, emotional instability, personality disorder, eczema, incontinence, hypotension, abnormal ECG, heart failure, constipation, gastritis, fecal incontinence, dyspepsia, increased γ-GT, gastric ulcer, dysphagia, periodontitis, gastric ulcer, periodontal abscess, abdominal bloating, abnormal liver function, belching, esophagitis, rectal bleeding, diabetes, anemia, leukocytosis, weight loss, peripheral edema, edema, increased LDH, increased alkaline phosphatase, hypercholesterolemia, hypokalemia, hypoglycemia, weight gain, hyperbilirubinemia, increased BUN, B12 deficiency anemia, cachexia, increased creatinine, gout, hyponatremia, hypoproteinemia, iron deficiency anemia, increased AST, increased ALT, arthritis, arthrosis, bone fractures, arthralgia, leg cramps, osteoporosis, anxiety, agitation, convulsions, psychotic symptoms, gait abnormalities, flat affect, delusions, dream disorder, cerebrovascular abnormalities, increased salivation, ataxia, euphoric state, vasodilation, cerebral hemorrhage, cerebral infarction, cerebral ischemia, dementia, extrapyramidal symptoms, generalized tonic-clonic seizures, hemiplegia, hypertonia, reduced motor activity, pharyngitis, pneumonia, increased coughing, bronchitis, respiratory distress, rhinitis, asthma, rash, skin ulcers, itching, psoriasis, skin discoloration, shingles, dry skin, sweating, hives, vesicular rash, conjunctivitis, glaucoma, visual disturbances, ear pain, tear disturbances, urinary tract infection, cystitis, hematuria, diabetes, vaginitis, urination disorders, frequent urination, proteinuria, abdominal pain, anxiety, cholecystitis, confusion, convulsions, heart block, hemolytic anemia, hyponatremia, neuroleptic malignant syndrome, pancreatitis

This medication should be stored in a tightly sealed container to prevent air or moisture exposure. It is recommended to maintain storage temperature between 1 and 30 degrees Celsius to preserve the efficacy of the medication.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle