Apam Tablet 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer 250 mg of famciclovir per dose orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of first-episode genital herpes Adults: Administer 250 mg of this medicine per dose orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer 125 mg of this medicine per dose orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine per dose orally twice daily. Discontinue treatment periodically every 6～12 months to observe whether the natural course of the disease has changed. 5. Patients with renal impairment: Since creatinine clearance of this medicine is decreased in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and first-episode genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula: Men: {weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, it is preferable to administer the medicine every 48 hours, taking the interval between dialysis sessions into account. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used in patients who have had allergies or hypersensitivity reactions to certain components. Also, this medication contains lactose, so it should not be administered to patients with genetic disorders that affect lactose digestion. Patients with impaired kidney function should be more cautious when using this medication and dosage adjustments may be needed as necessary. During the course of this medication, side effects such as headache, dizziness, nausea, vomiting, rash, etc. may occur, so if any abnormal symptoms arise, consult a healthcare professional. As this medication does not cure genital herpes, it is important to avoid sexual contact during symptoms and maintain safe sexual practices. If symptoms such as dizziness or drowsiness occur while taking this medication, one should refrain from driving or operating machinery. In patients with severely impaired liver function, the effectiveness may be reduced, so caution is required. There may be interactions with other medications, so it is important to inform healthcare professionals of any other drugs being taken. For women who are pregnant or breastfeeding, it is important to carefully consider the benefits and risks before using this medication. It is advisable not to use this medication in children under 18 years of age, as safety and efficacy have not been established. In case of overdose, seek medical attention promptly for proper treatment, and blood dialysis can reduce drug concentration.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication is sensitive to air and moisture, so it must be stored in a sealed container. It is also advisable to keep it in a cool, dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

21 tablets/box [7 tablets/PTP X 3]