Entirobatin Tablet 20mg (Rosuvastatin Calcium)

Adult dosage

This medication can be administered at any time of day, regardless of meals. The initial dose is 5 mg once daily, and the maintenance dose is typically 10 mg once daily for most patients. The maintenance dose should be adjusted based on LDL-cholesterol levels, treatment goals, and patient response at intervals of 4 weeks or more, with a maximum daily increase to 20 mg.

Children's dosage

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17 years) is 5 mg to 20 mg once daily. The dosage should be adjusted according to the individual treatment goals of each patient.

This medication should not be used in certain patients. For example, patients with allergies to any ingredient in this medication, patients with severely impaired liver function, patients with muscle diseases, and patients with severe renal impairment should not take this medication. Furthermore, women who are pregnant or breastfeeding, and women of childbearing potential should avoid using this medication without proper contraception. This medication can pose a risk of muscle issues, so patients with a history of muscle disease or a family history of such conditions, as well as those with hypothyroidism or alcoholism, should be particularly cautious. This medication contains lactose, and should not be administered to patients with genetic issues like lactose intolerance. Patients who consume excessive alcohol or have liver disease should undergo liver function tests before taking this medication and should continue regular checks during treatment. If symptoms of muscle pain or weakness occur, patients should inform their physician immediately, and stop using the medication if necessary. High doses of this medication may affect kidney function, so kidney function tests may also be needed. Asian patients may exhibit higher bodily concentrations of this medication, indicating a need for dosage adjustment. This medication can interact with other drugs, so patients taking other medications should consult their physician or pharmacist. It should not be used during pregnancy or breastfeeding, and women planning to become pregnant must ensure contraception. In case of overdose, there is no specific antidote, so treatment should be symptomatic and liver function and muscle enzyme levels should be monitored. Dizziness may occur when taking this medication, so caution is needed while driving or operating machinery. This medication can rarely cause serious skin reactions or liver damage, so if skin rashes or jaundice symptoms occur, the medication should be stopped immediately and medical advice sought. Overall, this medication requires regular monitoring of liver and muscle health and should be taken carefully according to a physician's instructions.

Serious side effects

Hypersensitivity reactions including angioedema, pancreatitis, myopathy (including myositis), rhabdomyolysis, polyneuropathy, memory loss, peripheral neuropathy, severe muscle weakness, respiratory distress, ocular muscle weakness, thrombocytopenia, jaundice, hepatitis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), immune-mediated necrotizing myopathy, acute renal failure, oliguria.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• muscle pain
• weakness
• hematuria
• diarrhea

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is between 1 to 30 degrees Celsius. This helps maintain the medication's efficacy and safety for an extended period.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/PTP [15 tablets/PTP x 2 packs], 30 tablets/bottle, 100 tablets/bottle