Dermatox Soft Capsule 10mg (Alitretinoin)

Adult dose

Take 10~30mg once daily with a meal or immediately after a meal. It is preferable to take it at the same time each day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: The initial dose is 10mg and may be increased to 30mg if necessary, depending on tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be needed during treatment with this medicine. Discontinue treatment as soon as the treatment goal of clear or almost clear hands is achieved. Discontinue treatment if hand eczema remains severe after the initial 12 weeks of treatment, and also discontinue if the treatment goal has not been achieved by 24 weeks of treatment.

This drug can cause severe birth defects and should never be taken by pregnant women or women who may become pregnant. Great caution is required if pregnancy occurs while taking the drug as it may pose significant risks to the fetus. Women of childbearing potential must use two or more effective methods of contraception before, during, and after treatment. A test to confirm pregnancy must be done before taking this medication, and monthly pregnancy tests should be conducted during treatment. Very high blood triglyceride levels can lead to serious side effects such as acute pancreatitis, so regular blood lipid level checks are necessary. Certain conditions such as liver impairment, severe kidney impairment, and uncontrolled hypothyroidism prohibit use of this drug. Patients with a history of mental illness require careful monitoring as psychiatric symptoms such as depression or mood changes may worsen. This drug may cause side effects like headaches, dry skin, chapped lips, increased triglycerides and cholesterol; any unusual symptoms should prompt consultation with a doctor. Avoid excessive sun exposure, use sunscreen, and refrain from vigorous exercise. If you experience dry eyes or changes in vision, appropriate measures should be taken and treatment may need to be discontinued if necessary. This drug may pose risks when taken with other vitamin A preparations or certain antibiotics, so it's crucial to inform the doctor of all medications being taken. Follow the doctor's and pharmacist's guidance strictly in accordance with the pregnancy prevention program, and maintain pregnancy prevention measures for a period after treatment ends. This medication is restricted for use in children and should not be taken by breastfeeding women. It should be taken with food or immediately after a meal, and should not be chewed. Store this medication in its original container in a cool place away from direct sunlight, and do not take expired medication.

• Headache
• erythema
• flushing
• increased triglycerides
• increased cholesterol
• decreased thyroid-stimulating hormone
• decreased free T4
• anemia
• increased iron-binding capacity
• decreased monocytes

This drug is sensitive to light and should be stored in a container that blocks light. It is also important to store it in a well-sealed container that prevents air exposure. The storage temperature should be maintained between 1 to 30 degrees Celsius, avoiding excessively hot or cold environments.

Appearance

Brownish black oval soft capsule containing a yellow to yellow-green uniform liquid

Package unit

30 capsules/box [(10 capsules/ptp*3)]