Dae Woong Bio Meropenem Injection 500 mg (Meropenem Trihydrate)

Adult administration

As meropenem hydrate, 0.5 to 1 g (potency) should be administered as an intravenous infusion divided into 2 to 3 doses over more than 30 minutes daily. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, 1 g (potency) should be infused intravenously every 8 hours. For cystic fibrosis and meningitis, 2 g (potency) should be administered intravenously every 8 hours. When using this drug, a decision regarding the continuation of treatment should be made based on a 3-day criterion after initiation, considering whether to stop the drug or switch to a more appropriate formulation.

Child administration

For bacterial meningitis in children over 3 months, the dose depends on the susceptibility of the pathogens and the patient's condition, with 40 mg per kg of body weight administered by slow intravenous infusion every 8 hours for more than 30 minutes.

This medication should not be used in patients with a history of shock. Additionally, patients taking valproate sodium should avoid using this drug, as it may lower valproate blood levels and increase the risk of seizure recurrence. Patients with hypersensitivity to this drug or its components, or those who have experienced such reactions in the past, should not be administered this drug. Patients who have had severe allergic reactions to other carbapenem antibiotics or beta-lactam antibiotics should also refrain from using this medication. Those with allergic tendencies or who suffer from bronchial asthma, rashes, etc., should use this drug cautiously, and patients with reduced kidney function may experience increased drug concentration leading to central nervous system symptoms, necessitating dose adjustment. Caution is also advised for patients with a history of seizures or central nervous system disorders due to the risk of convulsions. Careful administration is required in patients with severe liver impairment, the elderly, and infants (especially those under 3 months). During treatment, allergic reactions such as shock, rashes, or difficulty breathing may occur; if such symptoms arise, discontinue immediately and seek treatment. Regular blood tests are necessary, as leukopenia, anemia, or thrombocytopenia may occur. Liver and kidney functions should also be monitored regularly, and treatment should be suspended if abnormalities are found. Severe diarrhea symptoms akin to pseudomembranous colitis may occur, so if abdominal pain or diarrhea persists, medication should be discontinued immediately. If central nervous system symptoms such as convulsions or consciousness disturbances manifest, administration should be halted, and appropriate treatment should be obtained. If respiratory symptoms or severe skin reactions occur, administration must be stopped at once. Be cautious of bleeding tendencies due to vitamin K deficiency; monitor for bleeding symptoms. Caution is needed while driving or operating machinery, as headaches and mental confusion may occur. This drug may interact with certain medications, so consult with a physician regarding concomitant medications. Use in pregnant or breastfeeding women should be decided with caution, and it is advisable to avoid usage while breastfeeding. Safety in children, particularly infants under 3 months, has not been established, so caution is necessary. The elderly are at higher risk for side effects due to diminished physiological function, hence monitoring dosage and intervals is essential. This drug is to be administered intravenously only, and it must be used promptly after reconstitution and should be used within a specific time frame even when stored.

Serious side effects

• Shock
• anaphylaxis
• urticaria
• angioedema
• severe edema
• severe skin reactions
• toxic epidermal necrolysis
• Stevens-Johnson syndrome
• DRESS syndrome
• asthma attacks

Mild side effects

• Oral dysgeusia
• wheezing
• dizziness
• changes in bowel movements
• tinnitus
• sweating
• warmth
• erythema
• itching
• fever

This medication should be stored in a sealed container to prevent exposure to air and should safely be kept at room temperature, between 1°C and 30°C. This storage method helps to maintain the drug's efficacy and prevent degradation.

Appearance

A vial filled with a white to light yellow crystalline powder

Package unit

10 vials/box