Medication info
Nexiten Tablet 20 mg (Esomeprazole Magnesium Trihydrate)

Nexiten Tablet 20 mg (Esomeprazole Magnesium Trihydrate)

Prescription medicationTablet경구 · 정맥
Ingredient · strength
Esomeprazole Magnesium Trihydrate›22.25mg / 1 tablet
Manufacturer / importer
(주)라이트팜텍
Appearance
Pale pink round film-coated tablet
Packaging
28 tablets/box [(14 tablets/Alu-alu X 2)]
Approval status
Active

MFDS item code 201906915 · Approved 2019.09.30

Summary

Main use
Treatment of gastroesophageal reflux disease (including erosive reflux esophagitis), eradication of Helicobacter pylori, prevention of recurrence of peptic ulcers, and relief of gastrointestinal symptoms related to non-steroidal anti-inflammatory drugs.
Who uses it
Adults · Children
Adult dosage
This medication should be taken whole with liquids such as water and not chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. Symptomatic relief.
Children's dosage
Adolescents aged 12 years and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 1

Ingredients

Manufacturer
(주)라이트팜텍

Efficacy & effects

Treatment of gastroesophageal reflux disease (including erosive reflux esophagitis), eradication of Helicobacter pylori, prevention of recurrence of peptic ulcers, and relief of gastrointestinal symptoms related to non-steroidal anti-inflammatory drugs.

  • Gastroesophageal reflux disease
  • erosive reflux esophagitis
  • esophagitis
  • duodenal ulcer
  • peptic ulcer
  • upper gastrointestinal pain
  • upper gastrointestinal discomfort
  • upper gastrointestinal burning sensation
  • gastric ulcer
  • duodenal ulcer
  • Zollinger-Ellison syndrome
  • rebleeding from gastric ulcer
View approved original text

This medication is used for the treatment of gastroesophageal reflux disease, particularly for maintenance therapy to prevent recurrence of erosive reflux esophagitis. It is also effective for the treatment of duodenal ulcers and peptic ulcers in patients with Helicobacter pylori infection and for preventing recurrence. It helps in the treatment and prevention of upper gastrointestinal symptoms and gastric ulcers associated with the use of non-steroidal anti-inflammatory drugs. It is used in the treatment of Zollinger-Ellison syndrome and for maintenance therapy after preventing rebleeding from gastric or duodenal ulcers. This medication is very effective in improving and treating symptoms of gastrointestinal diseases.

Dosage and Administration

Adult dosage

This medication should be taken whole with liquids such as water and not chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. Symptomatic relief.

Children's dosage

Adolescents aged 12 years and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 1

Precautions

This medication should not be used in certain patients. It should not be administered if there is an allergy or history of hypersensitivity to this drug or its components, or to benzimidazoles. Additionally, antibiotics used for the eradication of Helicobacter pylori, such as penicillin or macrolide antibiotics, should not be taken in conjunction with this drug in case of allergy. Patients taking certain heart-related medications or antiviral drugs, as well as nursing women and patients with a history of myocardial infarction, should not use this medication. This drug contains Yellow No. 5 dye and should be used cautiously in patients allergic to this component. Various adverse reactions may occur when taking this drug, thus caution is required. For example, blood-related issues, allergic reactions, electrolyte imbalances, mental symptoms, gastrointestinal problems, skin rashes, muscle pain, etc., may occur. Particularly with long-term use, electrolyte abnormalities such as hypomagnesemia may arise, necessitating regular tests. Since this medication suppresses gastric acid secretion, it may slightly increase the risk of some bacterial infections. Therefore, if diarrhea symptoms persist, consult a physician. Prolonged use at high doses may increase the risk of fractures, so patients at risk of osteoporosis should be cautious. This medication can interact with several drugs, so if taking other medications, it is essential to inform your doctor or pharmacist, particularly regarding care when using in conjunction with warfarin, methotrexate, antiviral drugs, certain antibiotics, clopidogrel, etc. Due to limited safety data regarding this drug during pregnancy, it should be used cautiously, and its use is not recommended during breastfeeding. In the event of overdose, no specific antidote is available, so treatment should be symptomatic, and it should be kept out of reach of children. Lastly, if using this medication for an extended period or if symptoms change, it is advisable to consult a physician and to take the minimum effective dose and duration.

Side effects and when to seek care immediately

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, hypomagnesemia, hepatitis, jaundice, liver failure, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, DRESS syndrome, nephritis, severe allergic reactions, severe skin reactions, serious edema or urination abnormalities, rhabdomyolysis, severe skin reactions, seizures, convulsions, confusion, severe headache.

Mild side effects

Headache, dizziness, sensory abnormalities, drowsiness, taste disorders, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, oral mucositis, gastrointestinal candidiasis, increased liver enzymes, hepatitis, dermatitis, itching, rash, hair loss, photosensitivity, fractures, arthralgia, myalgia, nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal bloating, allergic reaction, etc.

Not everyone experiences these, and they can vary from person to person.

Storage

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. To maintain the drug's effectiveness, it should be stored at room temperature between 1°C and 30°C.

Appearance and packaging

Appearance

Pale pink round film-coated tablet

Package unit

28 tablets/box [(14 tablets/Alu-alu X 2)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.