Entiformin Tablet 500mg (Metformin Hydrochloride)

Adult dosage

The dosage is determined based on individual drug effects and tolerability, with a maximum daily dose of up to 2550mg. It should be administered 2-3 times a day, 500mg with meals. Dosage increases should be gradual, by 500mg weekly, and when administering 2000mg, it is usually divided into 2 doses in the morning and evening. If exceeding 2000mg, it should be divided into 3 doses with meals.

Children's dosage

Children and adolescents over 10 years of age should take 500mg once daily during or after meals. Blood sugar levels should be monitored one week later to adjust the dosage, with a maximum daily dosage of 2000mg.

This medication carries a risk of lactic acidosis and hypoglycemia, so caution is needed. It should not be administered to patients with moderate to severe renal impairment or in acute situations that may affect renal function, such as dehydration, serious infections, and acute myocardial infarction. Patients with acute or unstable heart failure or those preparing for tests using iodine contrast agents should also avoid this medication. Patients with a history of hypersensitivity to this medication or biguanides, type 1 diabetes, lactic acidosis, or diabetic ketoacidosis should not use it. Treatment should be temporarily stopped for patients with severe infections, severe traumatic systemic disorders, or those awaiting surgery, until their condition improves. Caution is also required for patients with liver dysfunction, lung function impairment, or excessive alcohol consumption. The medication must be used carefully in patients with irregular meals, insufficient food intake, vigorous exercise, or those taking interacting medications, as they may have an increased risk of lactic acidosis and hypoglycemia. Side effects such as gastrointestinal disturbances, metallic taste, skin rash, blood disorders, liver function abnormalities, and hypoglycemia may occur during treatment, and if symptoms manifest, immediate consultation with healthcare professionals is required. Renal function should be regularly monitored, and if it worsens, medication should be discontinued, particularly for elderly patients or those with declining renal function. Alcohol can affect lactate metabolism with this medication, so excessive consumption should be avoided. During pregnancy, the medication should not be given considering potential effects on the fetus, particularly in cases of placental insufficiency or risk of preeclampsia; consultations with healthcare professionals before planning or during pregnancy are advised. During breastfeeding, since this medication is excreted into breast milk, discussions with healthcare professionals should occur regarding stopping breastfeeding or discontinuing treatment. Special attention is necessary for children and elderly patients, particularly in adjusting doses based on renal function. This medication may affect blood sugar control when used in combination with other hypoglycemic agents, so close monitoring of the combination medication and the patient's condition is required. In case of overdose, blood dialysis may be required, so immediate visits to a healthcare facility should be made. This medication does not cause weight gain, which is advantageous for weight management, and long-term use helps achieve stable blood sugar control and reduce the risk of diabetes complications. Keep this medication out of the reach of children and do not transfer it to other containers.

Serious side effects

Lactic acidosis, severe allergic reactions (such as rash), renal function deterioration related to dehydration, liver abnormalities (liver function abnormalities increasing the risk of lactic acidosis), severe edema and hypertension, hypoglycemia (including severe delayed hypoglycemia)

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia, delayed hypoglycemia

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle