Unitok Soft Capsule 30mg (Alitretinoin)

Adult dose

Take 10~30mg once daily with or immediately after a meal. It is preferable to take it at the same time each day. The initial dose is 30mg of alitretinoin; reduce to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: The initial dose is 10mg; if necessary, it may be increased to 30mg according to tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be necessary during treatment with this medicine. Discontinue treatment as soon as the treatment goal of clear or almost clear hands is reached. Discontinue treatment if hand eczema remains severe after the initial 12 weeks of treatment, and also discontinue if the treatment goal has not been achieved by 24 weeks of treatment.

This medication must not be used in women who are pregnant or may become pregnant, due to a very high risk of causing serious fetal malformations. Effective contraceptive measures must be taken during the treatment, before starting the medication, and for some time after stopping it. It is important to undergo regular pregnancy tests to confirm pregnancy status. If blood triglyceride levels are very high, acute pancreatitis can occur, so blood lipid levels should be checked periodically, and if abnormalities are found, the physician should be consulted immediately. This medication should be prescribed by a physician experienced in systemic retinoid therapy, and patients must fully understand the side effects and risks associated with this drug. Pregnant women, nursing mothers, patients with liver disorders, severe renal impairment, patients with uncontrolled thyroid function, and patients with hypervitaminosis A should not take this medication. Patients with a history of mental illness or those showing symptoms of depression need to be cautious during treatment and should have their mental state continuously monitored. If new psychiatric symptoms occur, they must inform the healthcare provider immediately. This medication increases sensitivity to ultraviolet light, so it is advisable to avoid sun exposure and use sunscreen. Dry eyes, visual disturbances, and skin dryness may occur; if symptoms are severe, consult a physician. The risk of side effects increases when this drug is taken with other vitamin A preparations or tetracycline antibiotics, so concomitant use should be avoided. The medication should be swallowed with water during or immediately after a meal, and should not be chewed or crushed. During the treatment, blood donation is prohibited and should not be done for a certain period afterward. Store in a cool place out of reach of children, away from direct sunlight, and do not use expired medications. In case of overdose, since there is no specific antidote, seek medical attention immediately for appropriate treatment and monitoring, and male patients should avoid sexual relations with women of childbearing potential or use condoms for a certain period.

• Headache
• erythema
• flushing
• increased triglycerides
• increased cholesterol
• decreased thyroid-stimulating hormone
• decreased free T4
• anemia
• increased iron-binding capacity
• decreased monocytes

This drug is sensitive to light, so it should be stored in a tightly closed container that blocks light. Additionally, it is recommended to store the drug at room temperature between 1°C and 30°C. This storage condition helps maintain the drug's effectiveness and safety.

Appearance

A dark reddish oval soft capsule containing a uniform yellow to yellow-green liquid.

Package unit

30 capsules/box [10 capsules/PTP x 3]