Donepezil 10 mg (Donepezil Hydrochloride Hydrate)

Adult dosage

As Donepezil hydrochloride, administer 5 mg once daily before bedtime. After administering the 5 mg dose for 4-6 weeks, evaluate clinical response and can increase to 10 mg. When increasing to 10 mg daily, exercise caution for gastrointestinal adverse reactions. Underweight females aged 85 or older should not exceed 5 mg per day and require careful monitoring due to potential adverse reactions.

Children's dosage

There is no experience with the use in children.

This medication is used for the treatment of Alzheimer’s dementia symptoms and contains Donepezil hydrochloride as its main ingredient. First, this medication should not be used in certain patients. For example, individuals who are allergic to this medication or its ingredients, women who are pregnant or may become pregnant, and nursing mothers should not take this medication. Additionally, patients with genetic conditions that prevent the breakdown of lactose should also refrain from taking this medication. Second, patients with heart diseases, a history of asthma, chronic obstructive pulmonary disease, a history of peptic ulcers, those who are on non-steroidal anti-inflammatory drugs, and patients with extrapyramidal disorders like Parkinson's disease should use this medication with caution. This medication can slow down heart rate or cause arrhythmias, and it may exacerbate gastrointestinal symptoms. Various side effects can occur with this medication, so caution is needed. Common side effects may include nausea, vomiting, diarrhea, dizziness, and insomnia, while rare but serious side effects have been reported, including severe heart problems, liver dysfunction, cerebrovascular issues, and severe muscle symptoms. If any of these symptoms appear, consulting a doctor immediately is recommended. Moreover, this medication is not approved for other forms of dementia or memory decline aside from Alzheimer's dementia, and its therapeutic effects should be evaluated regularly. If no therapeutic effect is observed, discontinuation should be considered. This medication can affect the heart, so patients with heart conditions or electrolyte imbalances may require an electrocardiogram. Additionally, patients with a history of peptic ulcers should monitor for risks such as gastrointestinal bleeding. It may affect driving or machinery operation capabilities, so caution should be exercised if experiencing fatigue or dizziness during treatment. Pregnant or nursing women are advised against using this medication without consulting a specialist if absolutely necessary. This medication may interact with other drugs, so it is essential to inform physicians or pharmacists of any currently taken medications. Special caution is required when used together with heart-related medications, antibiotics, antidepressants, and antipsychotics. In cases of overdose, symptoms like severe vomiting, bradycardia, respiratory depression, and seizures may occur, and immediate medical treatment is necessary. Antidotes like atropine may be used in cases of overdose. Finally, this medication should be stored out of reach of children and should not be transferred to another container.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash accompanied by high fever, blisters, peeling skin, pain in oral/eye mucous membranes, shortness of breath or difficulty breathing, asthma attacks, breathing abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Nausea, vomiting, diarrhea, loss of appetite, headache, fatigue, dizziness, insomnia, drowsiness, anxiety, depression, hallucinations, agitation, aggressive behavior, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, thrombocytopenia, petechiae, myalgia, muscle cramps, urinary incontinence, frequent urination, fecal incontinence, increased salivation, rash, itching, facial swelling, edema, hypertension, lethargy, weight loss, hematological disorders (anemia, leukopenia

This medication should be stored in a tightly sealed container to prevent air ingress and kept at room temperature between 1°C and 30°C. Storing it this way will help maintain its effectiveness for a longer period.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle