Ranitidine Bismuth Citrate Tablet

Adult dosage

Typically, take one tablet twice daily, regardless of meals, in the morning and before sleep. 1) Gastric and duodenal ulcers: Take one tablet twice a day or take two tablets once a day before sleep. Especially for duodenal ulcer patients, taking two tablets twice a day in the morning and before sleep may achieve a higher treatment rate. The dosage is the same for the concomitant therapy to prevent ulcer development associated with NSAIDs or long-term NSAID use. Typically, diseases caused by NSAID use heal within 4 weeks, but in some cases may take longer depending on the patient. For patients with recurrent ulcers, who had excellent outcomes with this drug in short-term therapy, the maintenance therapy is to take one tablet once a day before sleep. 2) Gastroesophageal reflux disease: For 8 weeks, take one tablet twice a day or take two tablets once a day before sleep. For severe gastroesophageal reflux disease patients, the dosage may be increased to two tablets four times a day. 3) Zollinger-Ellison syndrome: Start treatment with an initial dose of one tablet three times a day and may adjust the dosage as needed. In cases of severe illness, as per the physician’s instructions, up to 6 g of ranitidine can be administered per day. 4) Peptic ulcer, acute stress ulcer, and upper gastrointestinal bleeding from acute mucosal lesions: Once oral administration is possible, switch from injection to oral and take one tablet twice a day. 5) Pre-anesthetic administration (prevention of Mendelson's syndrome): Take one tablet 2 hours before inducing anesthesia. Ideally, on the night before surgery, one tablet should also be taken.

This medication should not be used in patients undergoing dialysis treatment. Patients who have had an allergic reaction to this drug or its components should not be administered this medication. Patients with a history of acute porphyria should not use this drug as it may trigger seizures. It is safer not to use this drug in patients with poor renal function. Patients who have undergone upper gastrointestinal surgery are also advised not to receive this medication. Women who are pregnant or may become pregnant should not take this medication. This medication should not be given to premature infants or newborns. Patients on a potassium-restricted diet should preferably avoid this drug. Patients with impaired liver function or a history of drug allergies should use this medication with caution. Elderly patients or those with renal function issues should also take it with care. If used in conjunction with non-steroidal anti-inflammatory drugs, particularly in the elderly or those with a history of peptic ulcers, regular monitoring of their condition is necessary. This medication can mask symptoms of gastric cancer, so patients with gastric ulcers or those over middle age who have new or changed dyspeptic symptoms should check for malignancy prior to treatment. Patients with Helicobacter pylori-induced gastric or duodenal ulcers require eradication therapy. Severely ill patients in intensive care units should be cautious as this medication may lead to the formation of bezoars. Patients with hypophosphatemia should be careful since some components of this drug may interfere with phosphate absorption. Patients with swallowing difficulties may also experience respiratory complications after taking this medication, so caution is needed. While taking this medication, serious allergic reactions such as anaphylactic shock may rarely occur, so if symptoms arise, use should be immediately discontinued, and medical assistance should be sought. Allergic symptoms such as skin rash, urticaria, angioedema, fever, bronchospasm, hypotension, chest pain, etc., may also rarely appear, and if such symptoms occur, the medication should be stopped. Blood-related abnormalities including leukopenia, thrombocytopenia, and increased serum enzymes may occur rarely, and if symptoms are severe, administration should be stopped immediately. Liver function abnormalities may also occur rarely, so if jaundice or hepatitis symptoms appear, the medication should be discontinued. Irregular heartbeat or vasculitis has also been reported very rarely, so caution is needed if abnormalities arise. Gastrointestinal symptoms such as nausea, vomiting, constipation, diarrhea, and abdominal pain may appear infrequently, and stool may become black, but this does not require special treatment. Neurological symptoms such as dizziness, drowsiness, confusion, spasms, insomnia, headaches may rarely appear, so if symptoms occur, consultation with a healthcare professional is necessary. Muscle pain or joint pain may appear infrequently, and in severe cases, the medication should be discontinued. Skin rashes or hair loss have also been reported infrequently. This medication is best not taken for an extended period, and it should be used at the minimum effective dose while closely monitoring the course of treatment. If no effect is seen, switching to another medication is recommended. Elderly patients, those with chronic lung diseases, diabetes, and weakened immune systems may have an increased risk of pneumonia while taking this medication, so caution is advised. If dizziness or drowsiness occurs after taking it, it is advisable to avoid driving or operating hazardous machinery. This medication may interact with other drugs, so patients taking other medications should inform their healthcare provider. Particularly, when used with medications that affect blood coagulation, regular blood tests should be conducted to monitor the condition. Additionally, when taken with certain antibiotics or cardiac medications, it may affect drug absorption, so it is preferable to space out doses adequately. It is safe for women who are pregnant or nursing to avoid taking this medication. Safety for pediatric use has not been established, so it is preferable not to use it in children. In case of overdose, emergency treatment such as vomiting or gastric lavage may be performed, and if necessary, blood dialysis can be used for removal. This medication may reduce gastric acid secretion, which can promote bacterial proliferation in the gastrointestinal tract, so regular check-ups including ocular examinations may be required for long-term use.

Serious side effects

Urticaria, angioedema, shock, anaphylactic shock, bronchospasm, hypotension, chest pain (possible severe allergic reaction), skin rash (possible severe skin adverse reaction), angioedema, increased serum enzyme levels and jaundiced hepatitis (symptoms of liver dysfunction), altered consciousness, seizures, muscular spasms related to kidney dysfunction, rhabdomyolysis, acquired immune hemolytic anemia, agranulocytosis, pancytopenia, aplastic anemia, blood

Mild side effects

Skin rash, fever, angioedema, hypotension, chest pain, granulocytopenia, leukopenia, thrombocytopenia, increased serum enzyme levels, transient and reversible increases in AST, ALT, r-GTP, ALP, nausea, vomiting, constipation, diarrhea, abdominal bloating, abdominal pain, loss of appetite, dizziness, drowsiness, reversible states of confusion, excitement, insomnia, a feeling of heaviness, discomfort, anxiety, depression, hallucinations, gynecomastia, excessive milk secretion, erectile dysfunction,

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius (room temperature).

Appearance

Green rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle