Ofloxacine Tablet (Ofloxacin)

Adult dosage

○ The usual adult dose is 300～600 mg of ofloxacin daily, divided into 2～3 doses. ○ For Hansen's disease, the dose of this medicine is 400～600 mg daily, divided into 2～3 doses. In principle, it should be used in combination with other anti-Hansen's disease medicines. The dose may be adjusted as appropriate according to age and symptoms.

This drug may cause serious side effects, including tendonitis and tendon rupture, peripheral neuropathy, central nervous system abnormalities, and worsening of myasthenia gravis. If these symptoms occur, discontinue the use of this medication immediately, and fluoroquinolone drugs should not be administered to patients with myasthenia gravis. Additionally, this drug should be used cautiously in elderly patients, those with impaired kidney function, solid organ transplant recipients, and in combination with corticosteroids, as the risk of tendonitis and tendon rupture is increased. If symptoms of pain, inflammation, or tendon rupture occur, discontinue administration and refrain from physical activities until a clear diagnosis is established. This drug may increase the risk of seizures and exacerbate myasthenia gravis symptoms due to its neuromuscular blocking effects, hence caution is warranted for patients with epilepsy or central nervous system disorders. Patients who cannot be given this drug include those with hypersensitivity to this drug or similar medications, a history of tendonitis or tendon rupture, growing adolescents under 18 years, pregnant and breastfeeding women, G-6-PD deficiency patients, and those with a history of epilepsy. Caution is also necessary in patients with severely impaired renal function, the elderly, those with mental disorders, liver dysfunction, severe myasthenia gravis patients, and those with aortic aneurysms or heart valve abnormalities. This drug can trigger severe allergic reactions like anaphylaxis; if symptoms occur, discontinue immediately and seek appropriate treatment. Since it can affect the liver and kidneys, regular check-ups and monitoring are necessary. If severe diarrhea or abdominal pain appears as gastrointestinal side effects, discontinue immediately. Neurological side effects may include insomnia, dizziness, headaches, hallucinations, and confusion; treatment should be stopped if abnormal symptoms occur. Serious skin reactions may arise, so if rashes or blisters occur, discontinue immediately. Musculoskeletal side effects like myalgia, arthralgia, and, in severe cases, rhabdomyolysis may happen, so caution is warranted. There may also be abnormalities in the respiratory and circulatory systems; therefore, monitoring of symptoms is essential. This drug interacts with many other medications; particular caution should be exercised when combined with anticoagulants, antidiabetic agents, anti-inflammatory drugs, and antacids, and consultation with a physician is advised for combination therapy. This drug should not be administered to pregnant or potentially pregnant women, nor to nursing women; safety has not been established for children and adolescents. Older adults may have increased drug concentrations due to reduced kidney function, necessitating dosage adjustment and careful monitoring. During the course of treatment, avoid exposure to sunlight or artificial UV rays, maintain adequate hydration, and exercise caution when driving or operating hazardous machinery. In the event of overdose, contact a medical facility immediately for appropriate care, and when administering intravenously, it should be done slowly to reduce the risk of hypotension. Finally, this medication should be kept out of the reach of children and not transferred to other containers.

Tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects, exacerbation of myasthenia gravis, anaphylactic shock, anaphylactic reaction, rash, itching, erythema, edema, fever, warmth, blisters, erythema, photosensitivity reaction, hematuria, acute renal failure, kidney stones, interstitial nephritis, elevated BUN, elevated serum creatinine, jaundice, liver failure, elevated AST/ALT, elevated ALP, elevated γ-GTP, elevated total bilirubin, cholestatic jaundice, fulminant hepatitis, membranous colitis, colitis with bloody stools, nausea, vomiting, abdominal discomfort, diarrhea, cirrhosis, anorexia, abdominal pain, dyspepsia, chest pain, thirst, taste disturbances, stomatitis, glossitis, abdominal distension, constipation, dysphagia, gastrointestinal bleeding, oral mucosal pain, intestinal perforation, anemia, leukopenia, decreased hemoglobin, decreased hematocrit, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, petechial and purpuric bleeding, prolonged prothrombin time, reversible bone marrow suppression, lymphopenia, neutropenia, increased ESR, insomnia, dizziness, headache, seizures, tremors, paresthesia, peripheral neuropathy, visual disturbances, auditory disturbances, hallucinations, drowsiness, hyperexcitability, sleep disorders, confusion, anxiety, depression, restlessness, dysphoria, delirium, seizures, nightmares, paranoia, disorientation, attention deficit, memory impairment, delirium, suicidal thoughts, suicide, perceptual disturbances, reversible olfactory and vestibular sensory disturbances, ataxia, aphasia, heaviness of the head, skin mucosal syndrome, toxic epidermal necrolysis, arthralgia, myalgia, muscle weakness, myositis, malaise, elevated CPK, elevated serum myoglobin, elevated urinary myoglobin, pharyngitis, dyspnea, bronchospasm, allergic pneumonia, epistaxis, stridor, fever, cough, abnormal chest X-ray, eosinophilia, interstitial pneumonia, cerebral thrombosis, pulmonary edema, tachycardia, hypertension, hypotension, palpitations, vasodilation, circulatory collapse, QT prolongation, ventricular tachycardia, dysuria, frequent urination, urinary retention, anuria, polyuria, hematuria, urinary storage, pyuria, diabetes, proteinuria, alkaline urine, vaginitis, vaginal candidiasis, increased vaginal discharge, female genital itching, irregular menstruation, uterine cramping, female genital rash, pain, irritation, burning sensation, symptoms of hypoglycemia, limb pain, fatigue, fever, aortic aneurysm, aortic dissection, valvular regurgitation, valvular insufficiency, drowsiness, nausea, facial flushing, facial edema, paresthesia, inaccurate speech, loss of spatial orientation

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it should be kept at a safe temperature between 1 to 30 degrees Celsius. Proper storage will help maintain its efficacy for a longer period.

Appearance

White to off-white round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle