Prucalopride 1 mg (Prucalopride Succinate)

Adult dose

Administered orally, it can be taken at any time of the day regardless of meals. Adults take 2 mg once daily. For elderly patients aged 65 and older, an initial dose of 1 mg once daily may be prescribed, which can be increased to 2 mg once daily if necessary. For patients with severe renal impairment (GFR < 30 ml/min/1.73 m2) and severe liver impairment (Child-Pugh class C), the dose is 1 mg once daily.

This medication should not be used in certain patients. For example, patients with allergies to the active ingredient or excipients, patients with severely impaired renal function, and patients with serious bowel problems should not take this medication. This medication contains lactose, so patients with genetic disorders that prevent lactose digestion should also avoid it. Patients with severe renal impairment should use this medication cautiously at a reduced dose. Additionally, caution is needed for patients with liver disease, heart disease, lung disease, or neurological disorders. Patients with heart issues or a history of arrhythmias should use this medication with extra care. Patients with severely impaired liver function should also use it at a reduced dose, and caution is required when taken with other medications that can prolong the QTc interval. Gastrointestinal symptoms such as headache, abdominal pain, nausea, and diarrhea may commonly occur during the use of this medication, and these symptoms usually arise at the beginning of treatment and subside over time. Symptoms like dizziness, fatigue, and palpitations may also occur, so if these symptoms worsen, it is recommended to consult a doctor. Severe diarrhea may reduce the effectiveness of oral contraceptives, so it is advisable to use additional contraceptive methods. This medication generally has a low potential for interactions with other medications, but caution is warranted as its concentration in the blood may increase when taken with certain potent drugs. Use of this medication during pregnancy is not recommended, and women of reproductive age should use effective contraceptive methods while taking it. It is also not recommended for breastfeeding women to use this medication. It is better not to administer this medication to children or adolescents under 18 years of age. In cases of overdose, symptoms such as headache, nausea, or diarrhea may occur, and appropriate treatment should be obtained if necessary. This medication may cause dizziness and fatigue on the first day of administration, so caution is needed when driving or operating machinery. Lastly, this medication should be stored out of reach of children and in its original container, avoiding moisture.

Mild side effects

• Headache
• dizziness
• tremors
• palpitations
• nausea
• diarrhea
• abdominal pain
• vomiting
• indigestion
• rectal bleeding

This medication is sensitive to light, so it should be stored in a container that does not allow light to enter. Additionally, avoid humid places and store it at room temperature between 1 and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

28 tablets/box [7 tablets/PTP*4]