Tirinta Tablet 60mg (Ticagrelor)

Adult dose

This medicine should not be used concomitantly with other ADP receptor inhibitors (ticlopidine, clopidogrel, prasugrel). Acute coronary syndrome: Administer an initial dose of 180mg, followed by 90mg twice daily. Treatment for 12 months is recommended unless discontinuation is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients with a history of myocardial infarction (occurring at least 1 year previously) who are at high risk of thrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients who received 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuing a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). The safety and efficacy of this medicine were evaluated at 3 years of follow-up. Patients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. For patients with acute coronary syndrome, refer to the dosage and administration for that condition. Data on the safety and efficacy of this medicine for treatment lasting more than 3 years are limited. Patients with acute ischemic stroke or high-risk transient ischemic attack: Administer an initial dose of 180mg, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial loading dose of aspirin (300-325mg) is recommended in patients with acute ischemic stroke or high-risk transient ischemic attack. This medicine is administered orally and may be taken with or without food. For patients who have difficulty swallowing tablets, crush this medicine into a fine powder, disperse it in half a glass of water, and drink the mixture. Rinse the glass with another half glass of water and drink it. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the tube with water after administration. When switching from another antiplatelet agent to this medicine, start treatment with this medicine 24 hours after the last dose of the previous medicine. If a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. No dose adjustment is necessary in patients with renal impairment. No dose adjustment is necessary in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience with its use in patients with moderate hepatic impairment is limited.

Child dose

Pediatric patients younger than 18 years: Safety and efficacy have not been established (see “Other” section).

This medication helps prevent platelets in the blood from clumping together to form clots, allowing blood to flow more easily. However, it can increase the risk of bleeding, so it should not be used in patients who have current bleeding or a history of cerebral hemorrhage. It is crucial to stop taking this medication at least 5 days before undergoing surgery and to resume it according to a doctor's instructions after surgery. If bleeding symptoms occur, consulting a doctor immediately is essential, and treatment of the bleeding should proceed if possible without discontinuing this medication. This medication should not be used in cases of allergy to its components, severe liver disease, or if taken with certain powerful medications. Patients at high risk for bleeding, those scheduled for surgery, or patients with bradycardia or respiratory distress symptoms should use this medication with caution. In particular, patients with asthma or chronic lung diseases should be careful as respiratory distress may worsen. This medication can increase uric acid levels in the blood, so caution is warranted for patients with a history of gout. In addition, as this medication may interact with other drugs, it is important to inform the doctor or pharmacist of any concurrent medications. Pregnant or breastfeeding women should consult a specialist before using this medication, and women planning to become pregnant should avoid pregnancy while taking this medication. This medication is not recommended for use in children under 18 years of age as its safety and efficacy have not been established for this age group. Overdose may increase the risk of bleeding, so it is essential to adhere to the prescribed dosage, and if abnormal symptoms occur, contact a medical institution immediately. This medication may cause symptoms such as dizziness or confusion, so caution is needed when driving or operating machinery. Lastly, this medication should be stored out of reach of children, and it is safest to keep it in its original container.

Hemorrhage, intracranial hemorrhage, ocular hemorrhage, ear hemorrhage, hypotension, dyspnea, respiratory tract hemorrhage, gastrointestinal hemorrhage, diarrhea, nausea, dyspepsia, constipation, retroperitoneal hemorrhage, skin hemorrhage, rash, pruritus, muscle hemorrhage, urinary tract hemorrhage, reproductive tract hemorrhage, post-procedural hemorrhage, traumatic hemorrhage, thrombotic thrombocytopenic purpura, bradyarrhythmia, atrioventricular block, thrombosis, deep vein thrombosis, cardiac thrombus, thrombocytosis, thrombocytopenia, hematoma, cerebral hemorrhage, confusion, dizziness, syncope, headache, vertigo, elevated serum creatinine, hyperuricemia, gout, chest pain, pulmonary hemorrhage, pharyngitis, upper respiratory tract infection, asthma, pleural effusion, bronchitis, pneumothorax, pneumonia, pulmonary edema, asthenia, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal canal stenosis, dementia, migraine, paralysis, gait abnormality, rectal hemorrhage, anal hemorrhage, appendicitis, tendinopathy, bursitis, rhabdomyolysis, hepatitis, snoring, aneurysm, heart failure, cardiac arrhythmia, palpitations, ventricular tachycardia, arrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary tract infection, nephrolithiasis, cerebral ischemia, venous stenosis, cerebral infarction, arterial stenosis, angina pectoris, coronary thrombosis, myocardial ischemia, arterial stenosis, angina pectoris, coronary thrombosis, cardiomyopathy, myocardial ischemia, cardiac compressive syndrome, anemia, vestibular dysfunction, malignant neoplasm of male genital organs, chemical poisoning, post-procedural hematoma, laceration, traffic accident, trauma, nausea, vomiting, acute renal failure, hyperkalemia, hyperglycemia, thirst, diabetes exacerbation, hepatitis, insomnia, anxiety, memory disturbance, erectile dysfunction, restlessness, orthostatic hypotension, hypertension exacerbation, palpitations, bradycardia, atrial fibrillation, increased urinary frequency, dysuria, urinary tract infection, ocular congestion, eye pain, visual disturbance, arterial stenosis, angina pectoris, myocardial infarction, reduced blood iron, tinnitus, ear pain, lymphadenopathy, eosinophilia, sexual dysfunction, benign prostatic hyperplasia, ovarian cyst, amenorrhea, vaginitis, loss of taste, abnormal smell, increased TSH, hypothyroidism, injection site reaction, injection site pain, urticaria, increased sweating, contact dermatitis, skin disease, erythematous rash, hyperkeratosis, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, abscess, fungal infection, oral candidiasis, shingles, bacterial infection, esophageal candidiasis, thrombosis, speech impairment, cerebral hypoxia, scalp tenderness, peripheral neuropathy, neck rigidity, voice disorder, seizure, neuropathy, neuralgia, dyskinesia, tremor, lower limb paralysis, coma, oral pain, gastroenteritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tendinitis, arthrosis, chondrocalcinosis, spinal osteoarthritis, arthritis, contact dermatitis, fungal dermatitis, skin disease, erythematous rash, hyperkeratosis, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, increased sweating, hypokalemia, hypocalcemia, unspecified lipid metabolism disorder, hyperkalemia, hypomagnesemia, hypoglycemia, elevated AST, elevated ALT, insomnia, anxiety, memory disturbance, erectile dysfunction, restlessness, orthostatic hypotension, hypertension exacerbation, heart failure, hypertension, palpitations, bradycardia, atrial fibrillation, palpitations, increased urinary frequency, acute renal failure, dysuria, urinary tract infection, cerebral infarction, phlebitis, ocular congestion, myocardial infarction, anemia, leukocytosis, benign prostatic hyperplasia, procedure site reaction, laceration

This medication should be stored in a tightly sealed container to prevent air or moisture ingress, ideally between 1 and 30 degrees Celsius. This storage method can help maintain the medication's effectiveness for a long period.

Appearance

Pink, double convex, round film-coated tablet

Package unit

60 tablets (10 tablets/PTP × 6)