Zanqpro 150 mg Tablet (Ranitidine Hydrochloride)

Adult dose

As ranitidine, 150 mg taken orally twice a day, once in the morning and once at bedtime. 1) Gastric and duodenal ulcers: 150 mg taken orally twice a day or 300 mg taken orally once a day at bedtime. Duodenal ulcer patients can take 300 mg orally twice a day, once in the morning and once at bedtime. For recurrent ulcer patients, maintenance therapy with 150 mg once a day is recommended.

Child dose

For children aged 8 to 18 years, 150 mg (2 mg per kg of body weight) can be administered once, up to twice a day.

This medication should not be used in patients with hypersensitivity to its components. It should not be administered to patients with a history of acute porphyria, as it may provoke seizures. Patients with genetic issues such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take this medication. Patients with impaired renal function may require dosage adjustments as it is excreted through the kidneys, which could lead to increased plasma concentrations. Patients with liver dysfunction should take this medication with caution. Past experiences of drug hypersensitivity and elderly patients should also be treated carefully. In cases where this medication is taken with nonsteroidal anti-inflammatory drugs (NSAIDs), elderly patients or those with a history of digestive ulcers require regular monitoring. It may obscure symptoms of gastric cancer, therefore, patients with gastric ulcers or those who are middle-aged or older and have experienced recent or changing dyspeptic symptoms should confirm malignancy before taking. Patients with Helicobacter pylori-positive gastric and duodenal ulcers require bacterial eradication treatment. This medication can rarely cause hypersensitivity reactions such as anaphylactic shock, hives, and angioedema, so if any unusual symptoms occur, usage must be stopped immediately. Various side effects could occur, such as blood abnormalities, liver dysfunction, heart rhythm disorders, gastrointestinal symptoms, and neurological issues, so patients should consult healthcare professionals if symptoms arise. Particularly, patients with impaired renal function, the elderly, and severely ill patients may present neurological symptoms such as confusion or seizures, so caution is warranted. The medication should be used at the minimal effective dose while monitoring therapeutic effects, and alternative treatments should be considered if no efficacy is observed. Elderly patients, chronic pulmonary disease patients, diabetic patients, and those with weakened immunity may have an increased risk of pneumonia, thus they should be cautious. If dizziness or drowsiness occurs, driving or operating dangerous machinery should be avoided. This medication may interact with other drugs, particularly anticoagulants, thus the coagulation state should be closely monitored. When taken with sucralfate, absorption may be decreased, so they should be taken at least 2 hours apart. Women who are pregnant or may become pregnant should take this medication only when its benefits outweigh the risks, and caution is also advised when breastfeeding. The safety in children has not been adequately established. Elderly patients may experience increased plasma concentrations due to renal function decline, hence dosage and administration intervals should be adjusted. In cases of overdose, special problems are rare; however, appropriate measures such as vomiting or gastric lavage should be taken, and if necessary, blood dialysis can be performed to eliminate the drug. This medication should be stored out of reach of children, and transferring it to other containers is not advisable for quality maintenance and safety.

Serious side effects

• Hives
• angioedema
• shock
• anaphylactic shock
• bronchospasm
• difficulty breathing
• chest pain
• severe allergic reactions
• skin peeling
• severe skin adverse reactions

Mild side effects

Rash, fever, angioedema, hypotension, chest pain, granulocytopenia, elevated serum creatinine levels, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, agranulocytosis, pancytopenia, acquired immune hemolytic anemia, eosinophilia, transient and reversible liver dysfunction (increased AST, ALT, γ-GTP, ALP levels), bradycardia, AV block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal discomfort

This medication is sensitive to light, so it must be stored in a special container that prevents light exposure. Additionally, the medication should be stored at room temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be preserved for a longer time.

Appearance

Cream to pale yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle