Lotrovant Tablets 5 mg (Rosuvastatin Calcium)

Adult dosage

This medication can be taken at any time of the day regardless of meals. The initial dose is 5 mg once daily, which can be adjusted to the maintenance dose. The maintenance dose is usually adjusted to 10 mg once daily for most patients. The maintenance dose should be appropriately adjusted at intervals of 4 weeks or more based on LDL-cholesterol levels, therapeutic goals, and patient response, with a maximum daily dose of 20 mg.

Children's dosage

The usual dosage range is 5 mg to 20 mg once daily. The dosing should be individually adjusted according to the recommended therapeutic goals for each patient. Dosage adjustments should be made at intervals of 4 weeks or more.

This medication should not be used in certain patients. For example, patients with allergies to this medication, severe liver dysfunction, muscle disorders, severe renal impairment, women who are pregnant or breastfeeding, and fertile women who do not use adequate contraception should not take this medication. Additionally, patients with muscle problems or risk factors for muscle damage should not take this medication in high doses. This medication contains lactose, so patients with lactose intolerance or specific genetic metabolic disorders should also avoid it. While taking this medication, liver function and muscle condition should be periodically tested, and patients who drink alcohol heavily or have a history of liver disease should be particularly cautious. If symptoms such as muscle pain, weakness, or cramps occur, the physician should be notified immediately, and a blood test should be performed to check for muscle damage. This medication may affect kidney function when taken in high doses, so kidney function tests may also be necessary. This medication may interact with other drugs, so if the patient is taking any other medications, they must inform their doctor or pharmacist. Special caution is needed when taken with certain antiviral drugs, immunosuppressants, antifungals, antibiotics, and fibrate medications. Women who are pregnant or breastfeeding should not take this medication, and women who may become pregnant should use adequate contraception. If this medication is taken during pregnancy, it should be stopped immediately and the physician consulted. There is no specific antidote for overdose, so treatment should be symptomatic, and liver function and muscle enzyme tests may be required. This medication is known not to significantly impact driving or machine operation abilities, but caution is advised due to potential dizziness. Rarely, serious skin reactions, liver damage, or muscle damage may occur, so if any unusual symptoms appear, medical personnel should be notified immediately. During the use of this medication, it is important to regularly monitor blood tests and health status as instructed by the physician.

Serious side effects

Allergic reactions including hives, angioedema, rhabdomyolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, severe muscle weakness, ophthalmoplegia, thrombocytopenia, fatal and non-fatal liver failure, acute renal failure, oliguria, severe edema, chest tightness, difficulty breathing, severe allergic reactions, severe skin reactions, respiratory difficulties, liver abnormalities (jaundice)

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It's best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets (10 tablets/Alu-AluX3), 30 tablets/bottle