Celecoxib Capsule 200mg (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient and may be administered with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) : As celecoxib, take 200 mg once daily, or 100 mg per dose in 2 divided doses daily. 2. Rheumatoid arthritis : As celecoxib, take 100 mg or 200 mg per dose twice daily. 3. Ankylosing spondylitis (AS) : As celecoxib, administer 200 mg once daily, or 100 mg per dose in 2 divided doses daily. If no effect is observed after 6 weeks, a dose of up to 400 mg daily may be administered. If no effect is observed after 6 weeks of treatment with 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea : The recommended initial dose is 400 mg of celecoxib; if needed, an additional 200 mg may be administered on the first day of treatment. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment : For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication can cause serious side effects, such as gastrointestinal bleeding, in individuals who regularly consume more than three alcoholic drinks a day; therefore, consultation with a doctor or pharmacist is essential. This medication may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, and these risks may increase with dosage and duration of use. Patients with a history of cardiovascular disease or risk factors should use the minimum effective dose for the shortest duration possible and consult healthcare professionals immediately if cardiovascular symptoms occur. This medication can cause serious adverse reactions such as gastrointestinal perforation, ulceration, and bleeding, especially in elderly patients or those with a history of gastrointestinal bleeding. If symptoms such as epigastric pain, indigestion, black stools, or hematemesis occur during use, immediate medical attention is necessary. This medication should not be administered to patients with specific allergy histories, severe liver or kidney dysfunction, active peptic ulcers, heart failure, or pregnant or nursing women. Patients with impaired liver or kidney function, asthma, hypertension, those with cardiovascular risks, and the elderly should use this medication cautiously and require regular monitoring. During the intake of this medication, side effects such as headache, indigestion, vomiting, diarrhea, dizziness, insomnia, skin rash, swelling, and elevated blood pressure may occur, and in severe cases, there is a risk of heart failure, liver dysfunction, kidney impairment, and myocardial infarction; therefore, immediate consultation with healthcare professionals is necessary in case of abnormal symptoms. This medication is metabolized in the liver; caution is needed when used in combination with other drugs that affect liver metabolism, and dosage adjustments may be necessary as the serum concentration of this medication can change when used with certain drugs. Pregnant women or women who may become pregnant should not use this medication, and nursing mothers should avoid its use or discontinue breastfeeding. Safety and efficacy in children and adolescents have not been established, so it is advisable not to use this medication in patients under 18 years of age. The elderly may have impaired liver and kidney function, requiring special caution when taking this medication and potential dosage adjustments. For those using this medication long-term, regular blood tests and liver and kidney function tests should be performed, and if abnormal findings are detected, administration should be halted immediately. In case of overdose, symptoms such as vomiting, drowsiness, lethargy, and gastrointestinal bleeding may occur, and immediate medical intervention is necessary. This medication should be kept out of reach of children and should not be transferred to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reaction, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequency of urination, nephrolithiasis, incontinence, urinary tract infection, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute kidney injury, interstitial nephritis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovitis, arthralgia, arthrosis, skeletal deformities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various parts, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic fasciitis, contact dermatitis, injection site reaction, skin nodules, headache, leg cramps, tension hypertonicity, sensory loss, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, exacerbation of allergies, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash associated with eosinophilia and systemic symptoms, acute generalized pustular psoriasis, exfoliative dermatitis, generalized bullous fixed drug eruption, fixed drug eruption, menstrual disorders, female infertility, hallucinations, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, gallstones, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, anaphylactic reaction

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, preferably at a cool room temperature between 15 to 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness and prevent deterioration.

Appearance

An opaque white capsule containing white to slightly yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle