Bearyl Tablet 4 mg (Glimepiride)

Adult dose

Individual titration is done for each patient. This medication is administered orally once daily, just before or immediately prior to the first meal. It should be swallowed whole with more than half a cup of water. In monotherapy, the initial dose is started at 1 mg of glimepiride once daily, with increments of 1 mg every 1 to 2 weeks. Generally, there is little added effect for dosages above 4 mg, but some patients may achieve better metabolic control with doses up to 6 mg.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a coma. Patients who are allergic to this medication or its components, including sulfonylureas or sulfonamides, should not use it. There is no experience of use in patients with severely impaired liver or kidney function, and it is recommended that these patients switch to insulin therapy. Women who are pregnant or may become pregnant, as well as nursing mothers, should not take this medication. Patients with severe infections, before or after surgery, or with severe trauma may require insulin therapy. Patients with gastrointestinal disorders such as diarrhea or vomiting may have an increased risk of hypoglycemia due to inadequate food absorption. This medication contains lactose and should not be administered to patients with lactose intolerance or certain genetic metabolic disorders. During the initial week of administration, there is a higher risk of hypoglycemia, so blood sugar levels should be monitored closely. This risk is particularly greater for the elderly, those with poor nutritional status or those who skip meals, patients with imbalanced exercise and carbohydrate intake, and those who frequently consume alcohol. Patients with weakened liver or kidney function may also be more sensitive to this medication, requiring caution. Additionally, dysfunction of the thyroid, pituitary, or adrenal glands may impact blood sugar control. There may be changes in blood sugar levels if this medication is overdosed or taken in combination with other medications. If symptoms of hypoglycemia occur, the doctor or pharmacist should be informed immediately, and dose adjustments may be necessary. The most common side effect of this medication is hypoglycemia, which can manifest as headaches, extreme hunger, nausea, fatigue, confusion, drowsiness, and loss of consciousness. Symptoms of hypoglycemia may also present as adrenergic responses such as sweating, cold skin, anxiety, and palpitations. Gastrointestinal disturbances such as visual disturbances, nausea, vomiting, abdominal pain, and diarrhea can also occur. Severe side effects such as liver dysfunction or decreased blood cell counts have been rarely reported, so any abnormal symptoms should be reported to a healthcare professional immediately. Allergic reactions such as hives, rash, difficulty breathing, and shock may occur; if these symptoms arise, the medication should be discontinued and medical attention sought urgently. This medication must be taken regularly alongside dietary and exercise therapies for optimal effectiveness, and it is crucial to consistently monitor blood sugar control. In the event of hypoglycemia, sugar or sweetened drinks should be consumed quickly to elevate blood sugar levels, as artificial sweeteners will not be effective. Under stress, during surgery, or with infections, blood sugar control may become difficult, necessitating a temporary switch to insulin therapy. Close monitoring for hypoglycemia and hyperglycemia is essential, especially during initial administration or dose changes, and caution is advised when driving or operating machinery. This medication is metabolized in the liver, so there may be interactions with certain medications; therefore, it is essential to inform the doctor or pharmacist if currently taking other medications. Particularly, changes in blood sugar levels may occur when used in combination with beta-blockers, antibiotics, anticoagulants, and corticosteroids. Pregnant or nursing mothers should avoid using this medication due to potential harm to the fetus or newborn and should switch to insulin treatment if necessary. Safety and efficacy have not been established in children under 18 years of age. In the elderly, renal function may decline, necessitating careful dosage adjustments. In the case of overdose, severe hypoglycemia may occur, requiring immediate medical treatment, and measures such as inducing vomiting or administering activated charcoal and glucose infusion may be needed. This medication should be stored out of the reach of children and kept in its original container for safety.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (skin or eye yellowing), profound lethargy, acute severe headache, thunderclap headache, seizures, confusion, visual abnormalities, paralysis, urination issues

Mild side effects

• Headache
• extreme hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced agility or initiative

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture, and it is safe to keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way will maintain the medication's efficacy and prevent degradation.

Appearance

Light blue rectangular tablet

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 100 tablets/bottle