Gleride Tablets (Glimepiride)

Adult dose

Adjusted individually for each patient. This medication is taken once daily by mouth. It should be taken before breakfast or immediately prior to the first meal. 1. Monotherapy - Initial dosage: Begin with an oral dose of 1 mg of glimepiride once daily. - Increase the dosage by 1 mg at 1 to 2-week intervals. - Generally, no additional effects are gained at doses exceeding 4 mg, although some patients may achieve improvement with doses of 6 mg.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a comatose state. Additionally, patients who have had allergic reactions to this medication, its components, or sulfonylureas should not be treated with this medication. There is limited experience with the use of this medication in patients with severely impaired liver or kidney function, and switching to regular insulin therapy is recommended. It is also safe for women who are pregnant or may become pregnant, as well as breastfeeding women, to avoid taking this medication. Insulin therapy is more appropriate for patients with severe infections, before and after surgery, or those who have suffered severe trauma. Patients with gastrointestinal disturbances such as diarrhea or vomiting should be cautious as they may have an increased risk of hypoglycemia due to improper food absorption. During the first week of medication, the risk of hypoglycemia is high, so blood sugar should be frequently monitored. Particularly, elderly patients, those with poor nutritional status, irregular meal patterns, or who have mismatched exercise and meal intake have a greater risk of hypoglycemia. Patients who consume alcohol frequently or have impaired kidney and liver function, as well as those with other endocrine disorders, may also be more sensitive to hypoglycemia. Caution should be exercised regarding blood sugar fluctuations if the medication is overdosed or used in conjunction with other medications. If such risk factors are present, it is important to consult with a physician to adjust the dosage or administration method. Hypoglycemia may occur with this medication, with symptoms including headache, severe hunger, nausea, fatigue, anxiety, decreased concentration, confusion, dizziness, drowsiness, and changes in consciousness. Symptoms such as cold, sweaty skin may also appear. Severe hypoglycemia can exhibit symptoms similar to a stroke, so immediately consuming food or drink containing sugar when symptoms arise is essential. Initially taking this medication may cause temporary blurring of vision or gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea, depending on blood sugar changes. Rarely, liver function abnormalities or changes in blood cell counts may also occur, necessitating regular testing. Allergic reactions such as itching, hives, and rashes may occur, and if serious reactions like difficulty breathing or decreased blood pressure manifest, immediate medical attention is required. It is important to optimize blood sugar control by incorporating dietary and exercise therapies while taking this medication. If hypoglycemia occurs, sugar or sugary drinks should be consumed immediately to alleviate symptoms, and it is advisable to always carry sugar for emergencies. Sufficient education about symptoms of hypoglycemia and risk factors should be provided to patients and their families. Additionally, this medication may interact with other drugs, so it is crucial to inform the physician or pharmacist when starting or stopping any other medications. Caution is necessary when used with medications that may affect enzymes that metabolize drugs in the liver. Some medications may enhance or diminish the blood sugar-reducing effects of this medication, thus adherence to the physician's instructions when taking medications is essential. It is safest for pregnant or breastfeeding women to refrain from taking this medication, and it is recommended to switch to insulin therapy if necessary. The safety and efficacy of this medication have not been established in children under 18. Elderly patients should have their medication doses adjusted carefully as kidney function may be impaired. In cases of overdose, severe hypoglycemia may occur, necessitating immediate medical attention for appropriate treatment, which may include inducing vomiting, administering activated charcoal, or glucose injection. This medication should be stored out of reach of children, in its original container and tightly sealed.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, pain in the oral/ocular mucosa, breathlessness, asthma attacks, respiratory difficulties accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), general weakness, sudden and very severe headache, thunderclap headache, seizures, confusion of consciousness, visual abnormalities, paralysis, significantly reduced urine output, systemic conditions.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggressiveness
• decreased concentration
• decreased agility or energy

This medication should be stored in a tightly sealed container to protect it from air and moisture exposure. A storage temperature of 1 to 30 degrees Celsius at room temperature is recommended. This will help maintain the medication's effectiveness for a longer period.

Appearance

Green, oblong tablets

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 300 tablets/bottle