Sepacool Capsule (Cefaclor Hydrate)

Adult dose

As cefaclor hydrate, administer 250mg per dose every 8 hours orally. In cases of severe infections, the dosage can be increased twofold. For acute gonococcal urethritis, this drug (3g) should be administered in a single dose in combination with probenecid (1g).

Child dose

Administer 20mg per kg of body weight divided every 8 hours. In the case of severe infections, otitis media, and infections with lower susceptibility, 40mg per kg of body weight can be administered daily, with a maximum dosage of

This medication should not be used in patients who have previously experienced shock due to this drug or who are allergic to this drug or cephalosporin antibiotics. It should be used cautiously in patients with a history of allergy to penicillin antibiotics or with a tendency to show allergic symptoms such as bronchial asthma, rash, and hives. Patients with very poor kidney function, those who have difficulty taking medications orally, the elderly, or patients in poor overall condition should be carefully monitored for vitamin K deficiency symptoms. Particular caution is required for patients with a history of gastrointestinal disorders, especially colitis. This medication can rarely cause shock or severe allergic reactions; if symptoms occur, it should be immediately discontinued, and appropriate treatment should be initiated. Serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis can occur, so caution is advised. Blood abnormalities can manifest as agranulocytosis, anemia, and thrombocytopenia, necessitating regular blood tests. There may be temporary liver function impairment, hepatitis, or jaundice symptoms, so liver status should be carefully monitored. Kidney function may be affected, leading to acute renal failure; therefore, regular kidney function tests are required, with immediate discontinuation if abnormalities occur. Gastrointestinal issues, including pseudomembranous colitis, diarrhea, nausea, or vomiting, may arise, so immediate consultation with a physician is necessary if severe abdominal pain or diarrhea occurs. Respiratory symptoms such as pneumonia or eosinophilia can rarely occur, and treatment should be discontinued if severe coughing or breathing difficulties arise. CNS symptoms such as anxiety, agitation, dizziness, drowsiness, and hallucinations can also rarely occur. Oral infections like stomatitis or candidiasis may occasionally occur as well. Vitamin K deficiency could lead to bleeding tendencies, so caution is advised for bleeding symptoms, and signs of vitamin B deficiency may also arise. To prevent the development of resistant bacteria, susceptibility tests should be performed, and the drug should only be administered for the necessary minimum duration. There may be interactions with other medications; caution is especially required when used concurrently with probenecid, nephrotoxic drugs, diuretics, anticoagulants, or oral contraceptives. Pregnant women or those who may become pregnant should carefully consider the risks and benefits of using this medication, and breastfeeding women should also use it cautiously. The safety of this medication in neonates, especially those under 1 month old, has not been established, so caution is warranted. Elderly individuals may experience adverse reactions more easily due to diminished bodily functions and higher risks of bleeding from vitamin K deficiency, thus dosage adjustment and monitoring of their condition are necessary. This drug works by binding to specific cell wall proteins and disrupting bacterial cell wall synthesis, thereby killing bacteria.

Serious side effects

Shock, symptoms of anaphylaxis such as difficulty breathing, vascular edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, granulocytopenia, pancytopenia, anemia, thrombocytopenia, aplastic anemia, hemolytic anemia, hepatitis, jaundice, elevated AST, ALT, ALP, reversible interstitial nephritis, increased BUN, elevated serum creatinine, acute renal failure, seizures, pseudomembranous colitis, severe colitis, cough, respiratory distress, convulsions.

Mild side effects

• Generalized flushing
• vascular edema
• sensory abnormalities
• syncope
• hypertension
• vasodilation
• rash
• itching
• fever
• lymphadenopathy

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the drug's effectiveness.

Appearance

A hard capsule with a purple upper part and white lower part containing a pale yellow powder.

Package unit

30 capsules/bottle, 300 capsules/bottle