Calof Tablet 1 mg (Prucalopride Succinate)

Adult dose

This medication is taken orally and can be administered at any time of day, regardless of meals. Adults take 2 mg once daily. Elderly patients aged 65 and older start with an initial dose of 1 mg once daily, and if necessary, the dose can be increased to 2 mg once daily. In patients with severe renal impairment and severe hepatic impairment, 1 mg is administered once daily. This medication should not exceed 2 mg per day.

This medication should not be used in certain patients. Patients with allergies to the active ingredients or excipients should not take it. Patients with severe renal impairment requiring dialysis should also refrain from using this medication. Those with serious gastrointestinal issues such as bowel perforation, bowel obstruction, or severe inflammatory bowel diseases like Crohn's disease or ulcerative colitis may also face risks when taking this medication. Additionally, this medication contains lactose, so individuals with lactose intolerance or related genetic disorders should not take it. Patients with severe renal impairment should use this medication cautiously, starting at a reduced dose. For patients with serious comorbidities such as liver disease, cardiovascular disease, pulmonary disease, neurological disorders, cancer, or AIDS, safety has not been fully established, and caution is necessary. In particular, patients with a history of cardiac arrhythmia or ischemic heart disease should use this medication carefully. It is recommended to administer a reduced dose to patients with severely impaired liver function. This medication should be used with caution in conjunction with other drugs that may prolong the QTc interval associated with heart rhythms. Taking this medication may commonly lead to headaches and gastrointestinal symptoms such as abdominal pain, nausea, and diarrhea. These symptoms usually occur early in treatment and often resolve over time. Other reported side effects include dizziness, tremors, palpitations, vomiting, dyspepsia, rectal bleeding, abdominal distension, frequent urination, fatigue, fever, malaise, dyspepsia, abdominal bloating, abdominal discomfort, gastroesophageal reflux disease, rectal pain, hemorrhoids, functional dyspepsia, soft stools, esophagitis, duodenal ulcers, nasopharyngitis, bronchitis, herpes zoster, tinea, bacterial vaginosis, bacterial bronchitis, facial edema, chest discomfort. If symptoms like heart palpitations arise, it is essential to consult a physician immediately. This medication may reduce the effectiveness of oral contraceptives during severe diarrhea, so it is advisable to use additional contraceptive methods. Although this medication has a low potential for interactions with other drugs, caution is warranted when used with certain potent metabolic inhibitors as it may alter drug concentrations. Special caution is necessary when used with drugs that may affect heart rhythms. Moreover, concomitant use with drugs similar to atropine may diminish the efficacy of this medication. Use of this medication during pregnancy is not recommended, and women of childbearing potential should use effective contraception while taking it. It is also advised not to administer this medication to children or adolescents. In cases of overdose, symptoms such as headache, nausea, and diarrhea may arise, and while there is no specific antidote, appropriate treatment according to symptoms may be necessary. If severe diarrhea or vomiting leads to fluid loss, electrolyte supplementation may be required. This medication may cause dizziness and fatigue on the first day of use, so care should be taken when driving or operating machinery. This medication should be stored out of reach of children and kept in its original container, avoiding exposure to moisture.

Serious side effects

• Palpitations
• ventricular extrasystole
• chest discomfort
• facial edema
• edema

Mild side effects

• Headache
• dizziness
• tremor
• palpitations
• nausea
• diarrhea
• abdominal pain
• vomiting
• dyspepsia
• rectal bleeding

This medication should be stored in a container that protects it from light and air, and care should be taken to avoid moisture. The storage temperature should be between 1 and 30 degrees Celsius at room temperature.

Appearance

White to off-white, round film-coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu * 2)